Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
Reads0
Chats0
TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
Citations
More filters
Journal ArticleDOI
Epigenetic regulation in myelodysplastic syndromes: implications for therapy
Ernesto Vigna,Anna Grazia Recchia,Antonio Madeo,Massimo Gentile,Sabrina Bossio,Carla Mazzone,Eugenio Lucia,Lucio Morabito,Vincenzo Gigliotti,Laura De Stefano,Nadia Caruso,Pasquale Servillo,Stefania Franzese,Filippo Fimognari,Maria Grazia Bisconte,Carlo Gentile,Fortunato Morabito +16 more
TL;DR: How non-intensive epigenetic therapy can ‘re-programme’ gene expression patterns of abnormal hematopoiesis in MDS is discussed, and combination therapies represent potentially effective options for intermediate-2 and high-risk MDS.
Journal ArticleDOI
Effect of 5-azacytidine (5-azaC) on the induction of chromatid aberrations (CA) and sister-chromatid exchanges (SCE).
TL;DR: The 5-azaC was found to increase the frequency of both baseline and MMC-induced SCEs and X-ray-induced CA, and it was found that thefrequency of X-Ray-inducedCA did not increase.
Journal ArticleDOI
The epigenetics of adult (somatic) stem cells.
TL;DR: This review focuses on the epigenetic mechanisms that regulate adult (somatic) stem cell differentiation, beginning with the metabolic pathways and factors regulating chromatin structure and DNA methylation and the molecular biological tools that are currently available to study these processes.
Journal ArticleDOI
Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells
TL;DR: The results suggest that PR CpG island aberrant hypermethylation could be one molecular and genetic alteration in leukemia.
Journal ArticleDOI
Cytoplasmic modification of nuclear gene expression.
TL;DR: It is proposed that alterations in DNA methylation patterns may be a possible mechanism to explain cytoplasmic modification of nuclear gene expression.
References
More filters
Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.