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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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A Cytosine Methyltransferase Homologue Is Essential for Sexual Development in Aspergillus nidulans
TL;DR: The results demonstrate that a DMT homologue closely related to proteins implicated in RIP and MIP has an essential developmental function in a fungus that appears to lack both DNA methylation and RIP or MIP.
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Targeting Epigenetic Mechanisms: Potential of Natural Products in Cancer Chemoprevention
TL;DR: This review presents the key epigenetic targets and highlights natural products that modulate these epigenetic mechanisms and show their potential for cancer chemoprevention.
Journal ArticleDOI
Dietary Modulation of the Epigenome.
TL;DR: A substantial and growing body of research shows that nutrition plays a significant role in regulating the epigenome, and this work critically assesses this diverse body of evidence elucidating the role of nutrition in modulating the epigenomes and summarizes the impact such changes have on molecular and physiological outcomes with regards to human health.
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Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases.
TL;DR: This review focuses on epigenetic changes in non-small-cell lung cancer and recent preclinical and clinical studies targeting these changes, and indicates thatbinatorial epigenetic therapy has demonstrated encouraging clinical activity, but many relevant questions remain.
Brief report Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage
TL;DR: Age-related methylation of theOP-1 promoter may contribute to a decrease in OP-1 production in cartilage and a decreaseIn expression of OP- 1 responsive genes such as IGF-1, the IGF- 1R, and aggrecan.
References
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Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
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DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
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X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.