Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
Citations
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Modulation of fetal hemoglobin in sickle cell anemia.
TL;DR: A partial understanding of the pathophysiology of sickle cell disease has suggested one means of treatment—increasing the distribution and concentration of fetal hemoglobin in sickle erythrocytes, although this can be accomplished clinically with drugs like hydroxyurea
Posted ContentDOI
An epigenetic mechanism for cavefish eye degeneration
Aniket V. Gore,Kelly A. Tomins,James R. Iben,Li Ma,Daniel Castranova,Andrew M. Davis,Amy Parkhurst,William R. Jeffery,Brant M. Weinstein +8 more
TL;DR: It is discovered that DNA methylation mediates eye-specific gene repression and globally regulates early eye development and the most significantly hypermethylated and down-regulated genes in the cave morph are also linked to human eye disorders, suggesting the function of these genes is conserved across the vertebrates.
Dissertation
Molecular genetic investigation of mitochondrial dysfunction in relation to migraine susceptibility
TL;DR: There is a molecular genetic link between mitochondrial dysfunction and migraine susceptibility and this work has provided the foundation for further studies aimed at utilising the identified markers in improved migraine diagnostic and therapeutic strategies.
Journal ArticleDOI
Claudin11 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin, but Uncommon in Nevus Cell Nevi
TL;DR: CLDN11 proved to be an epigenetically inactivated tumor related gene in melanomagenesis, and analysis of CLDN11 methylation level represents a potential tool for assisting in the discrimination between malignant melanoma and nevus cell nevi.
Journal ArticleDOI
Exploitation of elevated pyrimidine deaminating enzymes for selective chemotherapy
TL;DR: Mise au point d'une chimiotherapie pour le traitement specifique des tumeurs utilisant des analogues de la deoxycytidine et the tetrahydrouridine envers les tissus tumoraux.
References
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Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.