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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut
Katja Schneider,Andreas Schiermeyer,Anja Dolls,Natalie Koch,Denise Herwartz,Janina Kirchhoff,Rainer Fischer,Sean M. Russell,Zehui Cao,David Richard Corbin,Lakshmi Sastry-Dent,W. Michael Ainley,Steven R. Webb,Helga Schinkel,Stefan Schillberg +14 more
TL;DR: This work reports the HDR-mediated gene exchange of expression cassettes in tobacco BY-2 cells using a designed zinc finger nuclease (ZFN) for high frequency, precise, targeted exchange of fragments of sizes that are commercially relevant in plants.
Journal ArticleDOI
Differentiation therapy of myelodysplastic syndromes : Fact or fiction?
TL;DR: The hypothesis of therapeutic induction of maturation, founded on in vitro data, should be supported by in vivo proof, i.e. by the identification of terminally mature cells with an abnormal karyotype.
Journal ArticleDOI
Azapyrimidine nucleosides: metabolism and inhibitory mechanisms.
TL;DR: 6-Azauridine and 5-azacytidine were used with certain success in human chemotherapy, the first one as a drug affecting recalcitrant psoriasis, the second one for the treatment of different forms of leukemia.
Journal ArticleDOI
Global analysis of DNA methylation and transcription of human repetitive sequences.
Béatrice Horard,Angéline Eymery,Geneviève Fourel,Nikita S. Vassetzky,Jacques Puechberty,Gérard Roizès,Kevin Lebrigand,Pascal Barbry,Aurélie Laugraud,Christian Gautier,Elsa Ben Simon,Frédéric Devaux,Frédérique Magdinier,Claire Vourc'h,Eric Gilson +14 more
TL;DR: The RepArray is a repeat-specific microarray composed of a representative set of human repeated sequences including transposon-derived repeats, simple sequences repeats, tandemly repeated sequences such as centromeres and telomeres that represents the first valuable tool for systematic and genome-wide analyses of the methylation and transcriptional status of the repetitive counterpart of the human genome.
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Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.
TL;DR: Recent studies focusing on certain epigenetic readers, writers, and erasers associated with cancer development are summarized and how newly discovered natural compounds and their derivatives could interact with these targets are summarized.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
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DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.