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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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Generation of phenotypic diversity and progression in metastatic tumor cells
TL;DR: A model for generating cellular phenotypic diversity based on the proposed mechanism for rapid generation of immunoglobulin molecular diversity in B cells may be applicable to malignant cells and to cells in general.
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Definition of the landscape of promoter DNA hypomethylation in liver cancer.
Barbara Stefanska,Jian Huang,Bishnu Bhattacharyya,Matthew Suderman,Michael Hallett,Ze-Guang Han,Moshe Szyf +6 more
TL;DR: It is found that MBD2 depletion in human HCC and adenocarcinoma cells resulted in suppression of cell growth, anchorage-independent growth and invasiveness as well as an increase in promoter methylation and silencing of several of the genes that are hypomethylated in tumors.
Journal ArticleDOI
Delay in the fetal globin switch in infants of diabetic mothers.
TL;DR: The normal increase in beta-globin production from pre-switch levels did not occur in 9 of 10 infants at term, as compared with 11 normal infants, in whom the switch occurred by 36 to 39 weeks of gestation.
Journal ArticleDOI
Decitabine--bedside to bench.
TL;DR: While at least part of decitabine's activity is through induction of hypomethylation and reactivation of critical genes, mechanisms independent from hypometHylation are also important for decitABine's antitumor activity.
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Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Reinhard Dammann,Undraga Schagdarsurengin,Limin Liu,Noreen Otto,Oliver Gimm,Henning Dralle,Bernhard O. Boehm,Gerd P. Pfeifer,Cuong Hoang-Vu +8 more
TL;DR: The data indicate that inactivation of the RASSF1A gene is a frequent event in pancreatic cancer and suggest an inverse correlation between RASSf1A silencing and K-ras activation.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.