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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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Total syntheses of chaetocin and ent-chaetocin
TL;DR: The first total synthesis of ent-chaetocin (1) was described in detail in this article, where radical bromination was used for α-oxidation of the diketopiperazine ring, and reductive radical coupling for construction of the dimeric core structure.
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Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome.
Heather Kirk,Heather Kirk,William T. Cefalu,David M. Ribnicky,Zhijun Liu,Kenneth J. Eilertsen +5 more
TL;DR: An overview of the field of epigenetics, epigenetic therapy, and the molecules currently receiving the most interest with respect to treatment is provided, and data on botanical compounds that show promise in this regard are reviewed.
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A prospective multicenter observational study of decitabine treatment in Korean patients with myelodysplastic syndrome.
Je-Hwan Lee,Jun Ho Jang,Jinny Park,Seonyang Park,Young Don Joo,Yeo Kyeoung Kim,Hoon Gu Kim,Chul Won Choi,Sung-Hyun Kim,Seong Kyu Park,Eunkyung Park,Yoo Hong Min +11 more
TL;DR: Decitabine treatment was feasible and effective in Korean patients with myelodysplastic syndrome, and the overall survival was significantly longer in patients showing hematologic improvement.
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Epigenetic regulation and molecular characterization of C/EBPα in pancreatic cancer cells
Takashi Kumagai,Tadayuki Akagi,Julian C. Desmond,Norihiko Kawamata,Sigal Gery,Yasufumi Imai,Jee Hoon Song,Dorina Gui,Jonathan W. Said,H. Phillip Koeffler +9 more
TL;DR: It is demonstrated that aberrant silencing, as well as, inappropriate cytoplasmic localization of C/EBPα causes dysregulation of its function, suggesting that C/ EBPα is a novel candidate tumor suppressor gene in pancreatic cancer cells.
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Frequent epigenetic inactivation of RASSF10 in thyroid cancer
TL;DR: The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer, but RASSF10 methylation was significantly increased in primary thyroid carcinoma compared to normal thyroid and follicular adenoma.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
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DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.