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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells.
TL;DR: The results support the notion that arsenite can induce the ERK1/2 signaling pathway to stimulate autophagy and DAPK promoter hypermethylation in human uroepithelial SV-HUC-1 cells and contribute to a better understanding of the carcinogenesis of arsenite.
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Decitabine: a promising epi-immunotherapeutic agent in solid tumors
TL;DR: It is proposed in this review that decitabine can be considered an epi-immunotherapeutic agent and the connections among its hypomethylating effect, immune-activated mechanisms and clinical activity in solid tumors are discussed, keeping in mind the goal of optimizing dosing schedules.
Journal ArticleDOI
Human ZNF312b Promotes the Progression of Gastric Cancer by Transcriptional Activation of the K-ras Gene
In-Sung Song,Nang Su Oh,Hyun-Taek Kim,Ga-Hee Ha,So-Young Jeong,Jeong-Min Kim,Dong-Il Kim,Hyang-Sook Yoo,Cheol-Hee Kim,Nam-Soon Kim +9 more
TL;DR: It is found that ZNF312b plays a role in tumor progression and metastasis in gastric cancer via transcriptional activation of the K-ras oncogene, resulting in an enhancement of the extracellular signal-regulated kinase signaling pathway that governs cell proliferation.
Journal ArticleDOI
The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells
Basudev Chowdhury,Andrew McGovern,Yi Cui,Samrat Roy Choudhury,Il-Hoon Cho,Bruce A. Cooper,Timothy Chevassut,Amy C. Lossie,Joseph Irudayaraj +8 more
TL;DR: This study provides novel insights on the therapeutic activity of DAC in the backdrop of the newly discovered derivatives of 5mC and suggests that 5hmC has the potential to serve as a biomarker for monitoring the clinical success of patients receiving DAC.
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Expression level and DNA methylation status of glutathione‐S‐transferase genes in normal murine prostate and TRAMP tumors
TL;DR: This work examined Gst gene expression and Gst promoter DNA methylation in normal murine prostates and Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) tumors to demonstrate downregulated Gst genes are downregulated in human prostate cancer.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
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DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
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X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.