Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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The fundamental role of epigenetic events in cancer
Peter A. Jones,Stephen B. Baylin +1 more
TL;DR: This review discusses patterns of DNA methylation and chromatin structure in neoplasia and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.
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The epigenomics of cancer.
Peter A. Jones,Stephen B. Baylin +1 more
TL;DR: Recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, are reviewed and the growing implications of these advances for strategies to control cancer are discussed.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Expression of a single transfected cDNA converts fibroblasts to myoblasts.
TL;DR: In this article, the major open reading frame encoded by this cDNA contains a short protein segment similar to a sequence present in the myc protein family, and the expression of one of these cDNAs transfected into C3H10T1/2 fibroblasts, where it is not normally expressed, is sufficient to convert them to stable myoblasts.
References
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Journal Article
Cytotoxicity and Mode of Action of 5-Azacytidine on L1210 Leukemia
TL;DR: This study attempts to determine the primary actions of 5-azacytidine (5-azaCR) on L1210 leukemia and finds that it inhibits the incorporation of tritiated thymidine or deoxyadenosine into DNA to a greater extent than it inhibitsThe incorporation oftritiated uridine into RNA.
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DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations
Cees Waalwijk,R.A. Flavell +1 more
TL;DR: DNA modification in a HapII site (CCGG) present in the major intron of the discontinuous rabbit beta-globin gene is analysed, and it is inferred that 50% of the CCGG sites in the beta- globin gene intron are methylated in these tissues.
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Biological Effects of 5-Azacytidine in Eukaryotes
TL;DR: 5-Azacytidine exhibits furthermutagenic, abortive, immunosuppressive, antimitotic, radioprotective and virostatic effects, and affects DNA and protein synthesis in embryonic tissues, cells intissue culture, regenerating livers, in bacteria and phages.
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Correlation between hypomethylation of DNA and expression of globin genes in Friend erythroleukemia cells.
TL;DR: The degree of hypomethylation of DNA and tRNA from FL cells induced to differentiate with dimethylsulfoxide and butyrate, and DNA isolated from cells exposed to any of the three inducers, suggest that methylation ofDNA may play a role in the regulation of gene expression.
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Methylated and unmethylated DNA compartments in the sea urchin genome
TL;DR: Sea urchin (Echinus esculentus) DNA has been separated into high and low molecular weight fractions by digestion with the mCpG-sensitive restriction endonucleases Hpa II, Hha I and Ava I, and each of these gene families belongs to the unmethylated DNA compartment in all the tissues examined.