Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.
TL;DR: In this article, the main results of epidemiological studies on the impact of in utero exposure to maternal tobacco smoking on epigenetic mechanisms, and technical issues and methods used in such studies were provided.
Book ChapterDOI
Cellular Resistance to Cadmium
TL;DR: This chapter focuses on the application of cultured cell systems to the study of cellular responses associated with exposure to Cd2+ and the physiologic and genetic factors that modulate cadmium toxicity.
Journal Article
Frequency of reactivation and variability in expression of X-linked enzyme loci.
TL;DR: The studies show that 5-azacytidine can induce heritable changes in the inactive human X chromosome resulting in the expression of G6PD activity at a level lower than that from an active human X chromosomes.
Journal ArticleDOI
Activation of intracistemal a particles by 5-azacytidine in mouse Ki-BALB cell line
J. Lasneret,M. Canivet,F. Hojman-Montes de Oca,Joëlle Tobaly,R. Emanoil-Ravicovitch,Jorge Peries +5 more
TL;DR: The results obtained in this system correlate the high IAP expression after drug treatment with a demethylation of IAP-related genes sequences.
Journal ArticleDOI
Studies on the methylation of avian sarcoma proviruses in permissive and non-permissive cells.
TL;DR: It is suggested that modification of the sequence around the PvuI site results in reduced levels of transcription, as the methyl-sensitive restriction endonuclease Pvu I, which recognizes a unique site within the long terminal repeat in the ASV genome, failed to cleave proviruses present in several non-permissive host cells.
References
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Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.