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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells
TL;DR: Results demonstrate that combinatorial treatment consisting of a DNMT inhibitor (DNMTi) and an LSD1i have enhanced therapeutic values and could improve the efficacy of epigenetic therapy.
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Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage
TL;DR: In this article, an age-related decline in chondrocyte production of osteogenic protein-1 (OP-1) (Bone Morphogenetic Protein-7) may contribute to cartilage loss in osteoarthritis.
Journal ArticleDOI
Distinct modes of DNA accessibility in plant chromatin
TL;DR: It is shown that plants regulate DNA accessibility differently, and that restriction of DNA accessibility is a local property of chromatin and not necessarily a consequence of microscopically visible compaction.
Journal ArticleDOI
p53 Independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia
Kwok Peng Ng,Quteba Ebrahem,Soledad Negrotto,Reda Z. Mahfouz,Kevin A. Link,Zhenbo Hu,Xiaorong Gu,Anjali S. Advani,Matt Kalaycio,Ronald Sobecks,Mikkael A. Sekeres,Edward A. Copelan,Tomas Radivoyevitch,Jaroslaw P. Maciejewski,James C. Mulloy,Yogen Saunthararajah +15 more
TL;DR: In xenotransplant models of p53-null and relapsed/refractory AML, the non-cytotoxic regimen significantly extended survival compared with conventional cytotoxic cytarabine, and can bypass a mechanism of resistance to standard therapy.
Journal ArticleDOI
Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer
Maryse Lemaire,Guy G. Chabot,Noël J.-M. Raynal,Louise F. Momparler,Annie Hurtubise,Mark L. Bernstein,Richard L. Momparler +6 more
TL;DR: It is shown that intensification of the DAC dose markedly increased its antineoplastic activity in mouse models of cancer, and there is a good correlation between the concentrations of DAC that reduce in vitro clonogenicity, reactivate TSGs and inhibit DNA methylation.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
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DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
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X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.