Open AccessJournal Article
Gut bacteria in health and disease.
TLDR
Although this area holds much promise, more high-quality trials of probiotics, prebiotics, and other microbiota-modifying approaches in digestive disorders are needed, as well as laboratory investigations of their mechanisms of action.About:
This article is published in Gastroenterología y Hepatología.The article was published on 2013-09-01 and is currently open access. It has received 319 citations till now. The article focuses on the topics: Gut flora.read more
Citations
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Journal ArticleDOI
Human gut microbiota/microbiome in health and diseases: a review
TL;DR: The role of gut microbiota in maintaining host health is clarified and how nutritional and environmental factors affect the gut microbial structure and function is investigated.
Journal ArticleDOI
Gut microbiome and metabolic syndrome
TL;DR: Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.
Journal ArticleDOI
Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats
Siobhain M. O'Mahony,Valeria D. Felice,Kenneth Nally,Hélène M. Savignac,Marcus J. Claesson,Paul Scully,Jerzy A. Woznicki,Niall P. Hyland,Fergus Shanahan,Eamonn Martin Quigley,Julian R. Marchesi,Paul W. O'Toole,T. L. Dinan,John F. Cryan +13 more
TL;DR: A temporary disruption of the gut microbiota in early-life results in very specific and long-lasting changes in visceral sensitivity in male rats, a hallmark of stress-related functional disorders of the brain-gut axis such as irritable bowel disorder.
Journal ArticleDOI
Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
Anthony Lembo,Mark Pimentel,Satish S.C. Rao,Philip Schoenfeld,Brooks D. Cash,Leonard B. Weinstock,Craig Paterson,Enoch Bortey,William P. Forbes +8 more
TL;DR: In a phase 3 study of patients with relapsing symptoms of IBS-D, repeat rifaximin treatment was efficacious and well tolerated and significant improvements were noted for prevention of recurrence, durable response, and bowel movement urgency.
Journal ArticleDOI
Gut microbiota in neurodegenerative disorders.
TL;DR: This review summarizes the current understanding of the role of gut microbiota in neurodegenerative disorders and possible intervention strategies and reveals that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenersative disorders.
References
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Journal ArticleDOI
Relationship between dietary-induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in vivo.
TL;DR: Using the telemetry technique it was demonstrated that changes in the gastrointestinal microflora exhibited an intestinal motility response and, more importantly, that such changes can be initiated by the addition of synbiotics to the diet.
Journal ArticleDOI
The D-alanine content of lipoteichoic acid is crucial for Lactobacillus plantarum-mediated protection from visceral pain perception in a rat colorectal distension model
TL;DR: Reduction of the d‐alanine content of lipoteichoic acid in Lactobacillus plantarum (Dlt− mutant) enhanced its anti‐inflammatory properties in a mouse colitis model and inhibited visceral pain perception in healthy, non‐inflamed rats.
Journal ArticleDOI
The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease.
TL;DR: This article summarizes studies evaluating the efficacy of antibiotics and probiotics in the induction and maintenance of remission of ulcerative colitis, Crohn’s disease, and pouchitis.
Journal ArticleDOI
Probiotics, gut inflammation and barrier function.
Erika Isolauri,Seppo Salminen +1 more
TL;DR: Not only is the gut microbiota an essential constituent in the intestine’s defense barrier, it would appear that gut microbiota strains exercise a function in controlling and maintaining intestinal epithelial homeostasis.
Journal ArticleDOI
The microbiota in inflammatory bowel disease: friend, bystander, and sometime-villain
TL;DR: Clinification of the molecular basis of host-microbe interactions in health and in susceptible individuals promises novel therapeutic strategies.
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