Open AccessJournal Article
Gut bacteria in health and disease.
TLDR
Although this area holds much promise, more high-quality trials of probiotics, prebiotics, and other microbiota-modifying approaches in digestive disorders are needed, as well as laboratory investigations of their mechanisms of action.About:
This article is published in Gastroenterología y Hepatología.The article was published on 2013-09-01 and is currently open access. It has received 319 citations till now. The article focuses on the topics: Gut flora.read more
Citations
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Journal ArticleDOI
Human gut microbiota/microbiome in health and diseases: a review
TL;DR: The role of gut microbiota in maintaining host health is clarified and how nutritional and environmental factors affect the gut microbial structure and function is investigated.
Journal ArticleDOI
Gut microbiome and metabolic syndrome
TL;DR: Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.
Journal ArticleDOI
Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats
Siobhain M. O'Mahony,Valeria D. Felice,Kenneth Nally,Hélène M. Savignac,Marcus J. Claesson,Paul Scully,Jerzy A. Woznicki,Niall P. Hyland,Fergus Shanahan,Eamonn Martin Quigley,Julian R. Marchesi,Paul W. O'Toole,T. L. Dinan,John F. Cryan +13 more
TL;DR: A temporary disruption of the gut microbiota in early-life results in very specific and long-lasting changes in visceral sensitivity in male rats, a hallmark of stress-related functional disorders of the brain-gut axis such as irritable bowel disorder.
Journal ArticleDOI
Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
Anthony Lembo,Mark Pimentel,Satish S.C. Rao,Philip Schoenfeld,Brooks D. Cash,Leonard B. Weinstock,Craig Paterson,Enoch Bortey,William P. Forbes +8 more
TL;DR: In a phase 3 study of patients with relapsing symptoms of IBS-D, repeat rifaximin treatment was efficacious and well tolerated and significant improvements were noted for prevention of recurrence, durable response, and bowel movement urgency.
Journal ArticleDOI
Gut microbiota in neurodegenerative disorders.
TL;DR: This review summarizes the current understanding of the role of gut microbiota in neurodegenerative disorders and possible intervention strategies and reveals that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenersative disorders.
References
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Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination
Andrew S. Neish,Andrew T. Gewirtz,Hui Zeng,Andrew N. Young,Michael E. Hobert,Vinit Karmali,Anjali S. Rao,James L. Madara +7 more
TL;DR: The identification of enteric organisms (nonvirulent Salmonella strains) whose direct interaction with model human epithelia attenuate synthesis of inflammatory effector molecules elicited by diverse proinflammatory stimuli is reported.
Journal ArticleDOI
Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.
TL;DR: The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease, self-limiting colitis, irritable-bowel syndrome, and healthy controls were investigated by using a broad range of fluorescent bacterial group-specific rRNA-targeted oligonucleotide probes.
Journal ArticleDOI
Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
TL;DR: It is demonstrated that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes.
Journal ArticleDOI
The microbiome-gut-brain axis: from bowel to behavior.
TL;DR: It is shown that germ‐free mice display alterations in stress‐responsivity, central neurochemistry and behavior indicative of a reduction in anxiety in comparison to conventional mice, offering the enticing proposition that specific modulation of the enteric microbiota may be a useful strategy for stress‐related disorders and for modulating the co‐morbid aspects of gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease.
Journal ArticleDOI
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
TL;DR: Findings point to a more influential role for bifidobacteria in neural function, and suggest that probiotics may have broader therapeutic applications than previously considered.
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