Open AccessJournal Article
Gut bacteria in health and disease.
TLDR
Although this area holds much promise, more high-quality trials of probiotics, prebiotics, and other microbiota-modifying approaches in digestive disorders are needed, as well as laboratory investigations of their mechanisms of action.About:
This article is published in Gastroenterología y Hepatología.The article was published on 2013-09-01 and is currently open access. It has received 319 citations till now. The article focuses on the topics: Gut flora.read more
Citations
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The Effects of GH Transgenic Goats on the Microflora of the Intestine, Feces and Surrounding Soil.
Zekun Bao,Xue Gao,Qiang Zhang,Jian Lin,Weiwei Hu,Huiqing Yu,Jianquan Chen,Qian Yang,Qinghua Yu +8 more
TL;DR: It is demonstrated that expression of goat growth hormone in the mammary of GH transgenic goat does not influence the microflora of the intestine, feces and surrounding soil.
Journal ArticleDOI
Implication of gut microbiome in immunotherapy for colorectal cancer
Evangelos Koustas,Eleni-Myrto Trifylli,Panagiotis Sarantis,Nikolaos Papadopoulos,Georgios Aloizos,A. E. Tsagarakis,Christos Damaskos,Nikolaos Garmpis,Anna Garmpi,Athanasios G. Papavassiliou,Michalis V. Karamouzis +10 more
TL;DR: This paper will review the current literature observing how gut microbiota influence the response of immunotherapy on CRC patients, and suggest an optimal response for CRC patients to immunotherapeutic agents.
Journal ArticleDOI
Proteomic and microbial assessments on the effect of Antrodia cinnamomea in C57BL/6 mice
Yi-Ting Tsai,Jhen Wei Ruan,Cherng-Shyang Chang,Mei-Lan Ko,Hsiu-Chuan Chou,Chi-Chien Lin,Chiao-Mei Lin,Chih-Ting Huang,Yu-Shan Wei,En-Chi Liao,Hsin-Yi Chen,Li-Hsun Lin,Meng-Wei Lin,Cheng Yuan Kao,Hong-Lin Chan +14 more
TL;DR: In this paper, the authors performed two-dimensional difference gel electrophoresis (2D-DIGE) and MALDI-Biotyper to elaborate the AC-induced phenotypes on the intestine-liver axis and gut microbial distribution of C57BL/6 mice.
Journal ArticleDOI
Understanding and harnessing triple-negative breast cancer-related microbiota in oncology
TL;DR: A review of the current knowledge on bacterial relevance to triple negative breast cancer and potential uses is presented in this paper , where the authors examine some of the remaining unanswered questions regarding mechanisms underpinning observed effects.
IL-17 drives copper uptake and activation of growth pathways in colorectal cancer cells in a Steap4-dependent manner
TL;DR: Data are presented that show that colon cancer cells in which STEAP4 is overexpressed take up more copper from their environment than colon cancer, after which it becomes significantly more difficult to treat effectively.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI
Microbial ecology: Human gut microbes associated with obesity
TL;DR: It is shown that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet.
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Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
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