Open AccessJournal Article
Gut bacteria in health and disease.
TLDR
Although this area holds much promise, more high-quality trials of probiotics, prebiotics, and other microbiota-modifying approaches in digestive disorders are needed, as well as laboratory investigations of their mechanisms of action.About:
This article is published in Gastroenterología y Hepatología.The article was published on 2013-09-01 and is currently open access. It has received 319 citations till now. The article focuses on the topics: Gut flora.read more
Citations
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Journal ArticleDOI
Human gut microbiota/microbiome in health and diseases: a review
TL;DR: The role of gut microbiota in maintaining host health is clarified and how nutritional and environmental factors affect the gut microbial structure and function is investigated.
Journal ArticleDOI
Gut microbiome and metabolic syndrome
TL;DR: Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.
Journal ArticleDOI
Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats
Siobhain M. O'Mahony,Valeria D. Felice,Kenneth Nally,Hélène M. Savignac,Marcus J. Claesson,Paul Scully,Jerzy A. Woznicki,Niall P. Hyland,Fergus Shanahan,Eamonn Martin Quigley,Julian R. Marchesi,Paul W. O'Toole,T. L. Dinan,John F. Cryan +13 more
TL;DR: A temporary disruption of the gut microbiota in early-life results in very specific and long-lasting changes in visceral sensitivity in male rats, a hallmark of stress-related functional disorders of the brain-gut axis such as irritable bowel disorder.
Journal ArticleDOI
Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
Anthony Lembo,Mark Pimentel,Satish S.C. Rao,Philip Schoenfeld,Brooks D. Cash,Leonard B. Weinstock,Craig Paterson,Enoch Bortey,William P. Forbes +8 more
TL;DR: In a phase 3 study of patients with relapsing symptoms of IBS-D, repeat rifaximin treatment was efficacious and well tolerated and significant improvements were noted for prevention of recurrence, durable response, and bowel movement urgency.
Journal ArticleDOI
Gut microbiota in neurodegenerative disorders.
TL;DR: This review summarizes the current understanding of the role of gut microbiota in neurodegenerative disorders and possible intervention strategies and reveals that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenersative disorders.
References
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Journal ArticleDOI
DNA from probiotic bacteria modulates murine and human epithelial and immune function
Humberto Jijon,Jody Backer,Hugo Diaz,Helen Yeung,David Thiel,Conor McKaigney,Claudio De Simone,Karen L. Madsen +7 more
TL;DR: DNA from probiotic bacteria can limit epithelial proinflammatory responses in vivo and in vitro and systemic and oral administration of VSL3 DNA ameliorates inflammatory responses.
Journal ArticleDOI
Probiotics promote gut health through stimulation of epithelial innate immunity
Cristiano Pagnini,Rubina Saeed,Giorgos Bamias,Kristen O. Arseneau,Theresa T. Pizarro,Fabio Cominelli +5 more
TL;DR: The hypothesis that probiotics promote gut health through stimulation, rather than suppression, of the innate immune system is supported, which provides the perspective that defects in innate immunity may play a critical role in the pathogenesis and progression of intestinal disorders, such as inflammatory bowel disease.
Journal ArticleDOI
Techniques used to characterize the gut microbiota: a guide for the clinician
TL;DR: The techniques that can be used to characterize the gut microbiota, when they can be applied to human studies and their relative advantages and limitations are discussed.
Journal ArticleDOI
The host-microbe interface within the gut.
TL;DR: The use of germ-free animal models with selective colonization strategies combined with modern molecular techniques promises to clarify the molecular signals responsible for host-flora interactions in health and disease.
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