Open AccessJournal Article
Gut bacteria in health and disease.
TLDR
Although this area holds much promise, more high-quality trials of probiotics, prebiotics, and other microbiota-modifying approaches in digestive disorders are needed, as well as laboratory investigations of their mechanisms of action.About:
This article is published in Gastroenterología y Hepatología.The article was published on 2013-09-01 and is currently open access. It has received 319 citations till now. The article focuses on the topics: Gut flora.read more
Citations
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Journal ArticleDOI
Human gut microbiota/microbiome in health and diseases: a review
TL;DR: The role of gut microbiota in maintaining host health is clarified and how nutritional and environmental factors affect the gut microbial structure and function is investigated.
Journal ArticleDOI
Gut microbiome and metabolic syndrome
TL;DR: Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.
Journal ArticleDOI
Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats
Siobhain M. O'Mahony,Valeria D. Felice,Kenneth Nally,Hélène M. Savignac,Marcus J. Claesson,Paul Scully,Jerzy A. Woznicki,Niall P. Hyland,Fergus Shanahan,Eamonn Martin Quigley,Julian R. Marchesi,Paul W. O'Toole,T. L. Dinan,John F. Cryan +13 more
TL;DR: A temporary disruption of the gut microbiota in early-life results in very specific and long-lasting changes in visceral sensitivity in male rats, a hallmark of stress-related functional disorders of the brain-gut axis such as irritable bowel disorder.
Journal ArticleDOI
Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
Anthony Lembo,Mark Pimentel,Satish S.C. Rao,Philip Schoenfeld,Brooks D. Cash,Leonard B. Weinstock,Craig Paterson,Enoch Bortey,William P. Forbes +8 more
TL;DR: In a phase 3 study of patients with relapsing symptoms of IBS-D, repeat rifaximin treatment was efficacious and well tolerated and significant improvements were noted for prevention of recurrence, durable response, and bowel movement urgency.
Journal ArticleDOI
Gut microbiota in neurodegenerative disorders.
TL;DR: This review summarizes the current understanding of the role of gut microbiota in neurodegenerative disorders and possible intervention strategies and reveals that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenersative disorders.
References
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Reduced anxiety‐like behavior and central neurochemical change in germ‐free mice
Karen-Anne McVey Neufeld,N. Kang,N. Kang,John Bienenstock,John Bienenstock,Jane A. Foster,Jane A. Foster +6 more
TL;DR: This work has shown that the presence of gut microbiota regulates the set point for hypothalamic‐pituitary‐adrenal (HPA) axis activity, and the role intestinal microbiota may play in communication between these two systems is increasing.
Journal ArticleDOI
Low counts of Faecalibacterium prausnitzii in colitis microbiota.
Harry Sokol,Philippe Seksik,Jean-Pierre Furet,Olivier Firmesse,Isabelle Nion-Larmurier,Laurent Beaugerie,Jacques Cosnes,Gérard Corthier,P Marteau,Joël Doré +9 more
TL;DR: The fecal microbiota of patients with IBD differs from that of healthy subjects, and the phylum Firmicutes and particularly the species F. prausnitzii, are underrepresented in A‐IBD patients as well as in IC patients, which could be crucial to gut homeostasis.
Journal ArticleDOI
Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
Wolfgang Kruis,Fric P,J Pokrotnieks,Milan Lukas,B Fixa,M Kaščák,Michael A. Kamm,J Weismueller,Christoph Beglinger,M Stolte,C Wolff,J Schulze +11 more
TL;DR: The probiotic drug E coli Nissle 1917 shows efficacy and safety in maintaining remission equivalent to the gold standard mesalazine in patients with ulcerative colitis, which underlines the pathogenetic significance of the enteric flora.
Journal ArticleDOI
Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial.
TL;DR: The results suggest that treatment with a non-pathogenic E. coli has an equivalent effect to mesalazine in maintaining remission of ulcerative colitis.
Journal ArticleDOI
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
Marc-Emmanuel Dumas,Richard H. Barton,A. A. Toye,Olivier Cloarec,Christine Blancher,Alice R. Rothwell,Jane F. Fearnside,Roger Tatoud,Veronique Blanc,John C. Lindon,Steve Chappell Mitchell,Elaine Holmes,Mark I. McCarthy,James Scott,Dominique Gauguier,Jeremy K. Nicholson +15 more
TL;DR: Multivariate statistical modeling of the spectra shows that the genetic predisposition of the 129S6 mouse to impaired glucose homeostasis and NAFLD is associated with disruptions of choline metabolism, and indicates that gut microbiota may play an active role in the development of insulin resistance.
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