Journal ArticleDOI
Metalloporphyrins as versatile catalysts for oxidation reactions and oxidative DNA cleavage
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This article is published in Chemical Reviews.The article was published on 1992-09-01. It has received 1930 citations till now.read more
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A simple copper(II)-L-histidine system for efficient hydrolytic cleavage of DNA.
TL;DR: Study of the mechanism of plasmid DNA cleavage by added radical scavengers, using rigorously anaerobic experiments, analyses for malondialdehyde-like products, religation assays, and HPLC analyses, indicate thatDNA cleavage mediated by Cu(L-His) occurs via a hydrolytic path.
Journal ArticleDOI
Biomimetic modeling of oxidative drug metabolism : Strategies, advantages and limitations.
Wiebke Lohmann,Uwe Karst +1 more
TL;DR: This review summarizes three different nonenzymatic strategies, including metalloporphyrins as surrogates of the active centre of cytochrome P450, Fenton’s reagent, and the electrochemical oxidation of drug compounds.
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Multiple Active Oxidants in Cytochrome P-450 Model Oxidations
TL;DR: Evidence for the existence of distinct active oxidizing species in a cytochrome P-450 model system is reported and it is proposed that the active oxidant is a complex between the catalyst and the terminal oxidant.
Journal ArticleDOI
Synthesis, crystal structure, DNA binding and photo-induced DNA cleavage activity of (S-methyl-l-cysteine)copper(II) complexes of heterocyclic bases
TL;DR: Control DNA cleavage experiments suggest major groove binding propensity for the dppz complex, while the phen and dpq complexes bind at the minor groove of DNA, and chemically significant non-covalent interactions like hydrogen bonding involving the axial aqua ligand and pi-pi interactions between dppZ ligands.
Journal ArticleDOI
Metal-catalyzed asymmetric sulfoxidation, epoxidation and hydroxylation by hydrogen peroxide
TL;DR: In this paper, the use of non-heme systems for asymmetric sulfoxidation, epoxidation and dihydroxylation of alkenes has been discussed and the possibility of asymmetric oxidation catalyzed by metalloporphyrins has also been discussed.