Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence
Hua Chai,Blanca Diaz-Castro,Eiji Shigetomi,Emma Monte,J. Christopher Octeau,Xinzhu Yu,Whitaker Cohn,Whitaker Cohn,Pradeep S. Rajendran,Thomas M. Vondriska,Julian P. Whitelegge,Julian P. Whitelegge,Giovanni Coppola,Giovanni Coppola,Baljit S. Khakh +14 more
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TLDR
In this article, the authors used multiple integrated approaches, including RNA sequencing (RNA-seq), mass spectrometry, electrophysiology, immunohistochemistry, serial block-face-scanning electron microscopy, morphological reconstructions, pharmacogenetics, and diffusible dye, calcium, and glutamate imaging, to directly compare adult striatal and hippocampal astrocytes under identical conditions.About:
This article is published in Neuron.The article was published on 2017-08-02 and is currently open access. It has received 479 citations till now. The article focuses on the topics: Astrocyte.read more
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Reactive astrocyte nomenclature, definitions, and future directions
Carole Escartin,Elena Galea,Andras Lakatos,James P. O'Callaghan,Gabor C. Petzold,Gabor C. Petzold,Alberto Serrano-Pozo,Christian Steinhäuser,Andrea Volterra,Giorgio Carmignoto,Giorgio Carmignoto,Amit Agarwal,Nicola J. Allen,Alfonso Araque,Luis Barbeito,Ari Barzilai,Dwight E. Bergles,Gilles Bonvento,Arthur M. Butt,Wei Ting Chen,Martine Cohen-Salmon,Colm Cunningham,Benjamin Deneen,Bart De Strooper,Bart De Strooper,Blanca Diaz-Castro,Cinthia Farina,Marc R. Freeman,Vittorio Gallo,James E. Goldman,Steven A. Goldman,Steven A. Goldman,Magdalena Götz,Antonia Gutierrez,Philip G. Haydon,Dieter Henrik Heiland,Elly M. Hol,Matthew Holt,Masamitsu Iino,Ksenia V. Kastanenka,Helmut Kettenmann,Baljit S. Khakh,Schuichi Koizumi,C. Justin Lee,Shane A. Liddelow,Brian A. MacVicar,Pierre J. Magistretti,Pierre J. Magistretti,Albee Messing,Anusha Mishra,Anna V. Molofsky,Keith K. Murai,Christopher M. Norris,Seiji Okada,Stéphane H. R. Oliet,João Filipe Oliveira,João Filipe Oliveira,Aude Panatier,Vladimir Parpura,Marcela Pekna,Milos Pekny,Luc Pellerin,Gertrudis Perea,Beatriz G. Pérez-Nievas,Frank W. Pfrieger,Kira E. Poskanzer,Francisco J. Quintana,Richard M. Ransohoff,Miriam Riquelme-Perez,Stefanie Robel,Christine R. Rose,Jeffrey D. Rothstein,Nathalie Rouach,David H. Rowitch,Alexey Semyanov,Alexey Semyanov,Swetlana Sirko,Harald Sontheimer,Raymond A. Swanson,Javier Vitorica,Ina B. Wanner,Levi B. Wood,Jia Qian Wu,Binhai Zheng,Eduardo R. Zimmer,Robert Zorec,Michael V. Sofroniew,Alexei Verkhratsky,Alexei Verkhratsky +88 more
TL;DR: In this article, the authors point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic vs-neuroprotective or A1-vs.A2.
Journal ArticleDOI
Normal aging induces A1-like astrocyte reactivity
Laura E. Clarke,Shane A. Liddelow,Chandrani Chakraborty,Alexandra E. Münch,Myriam Heiman,Ben A. Barres +5 more
TL;DR: The aging-induced up-regulation of reactive astrocytes genes was significantly reduced in mice lacking the microglial-secreted cytokines known to induce A1 reactiveAstrocyte formation, indicating that microglia promote astroCyte activation in aging.
Journal ArticleDOI
Cell Biology of Astrocyte-Synapse Interactions
Nicola J. Allen,Cagla Eroglu +1 more
TL;DR: This review summarizes some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication and poses some pressing questions that need to be addressed to advance mechanistic understanding of the role ofAstrocytes in regulating synaptic development.
Supporting Online Material for Astrocytes Potentiate Transmitter Release at Single Hippocampal Synapses
Gertrudis Perea,Alfonso Araque +1 more
TL;DR: Results indicate that astrocytes are actively involved in the transfer and storage of synaptic information and mGluR-mediated but N-methyl-d-aspartate receptor–independent plasticity is observed.
Journal ArticleDOI
Generation of circadian rhythms in the suprachiasmatic nucleus.
TL;DR: The molecular, cellular and circuit mechanisms underlying time-keeping in the SCN are examined, which act as the principal pacemaker for circadian rhythms, which are powerful regulators of physiology and behaviour in mammals.
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Neurotoxic reactive astrocytes are induced by activated microglia
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