Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
Zilun Li,Meixiu Peng,Pin Chun Chen,Chenshu Liu,Ao Hu,Yixin Zhang,Jiangyun Peng,Jiang Liu,Yihui Li,Wenxue Li,Wei Zhu,Dongxian Guan,Yang Zhang,Hongying Chen,Jiuzhou Li,Dong-xiao Fan,Kan Huang,Fen Lin,Zefeng Zhang,Zeling Guo,He-wei Luo,Xi He,Yu Zhu,Linghua Li,Bingding Huang,Weikang Cai,Lei Gu,Yutong Lu,Kai Deng,Li Yan,Si-meng Chen +30 more
TL;DR: Zhang et al. as mentioned in this paper identified imatinib, methazolamide, and harpagoside as direct enzymatic activators of ACE2 and showed that these three compounds can improve metabolic perturbations in vivo in an ACE2-dependent manner under the insulin-resistant state and SARS-CoV-2-infected state.
Journal ArticleDOI
Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease
TL;DR: In this article, the authors discuss the mechanisms of anti-inflammatory effects of VNS, progress in selective VNS techniques, and a possible application for acute respiratory distress syndrome (ARDS).
Journal ArticleDOI
Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options.
Shetty Ravi Dyavar,Rahul Singh,Rohini Emani,Ganesh P. Pawar,Vinod D. Chaudhari,Anthony T. Podany,Sean N. Avedissian,Courtney V. Fletcher,Deepak B. Salunke +8 more
TL;DR: In this paper, the authors focus on inflammatory mediators that contribute to pathogenic effects and the role of TLR pathways in the induction of interferon and inflammatory mediator and their contribution to COVID-19 pathogenesis.
Journal ArticleDOI
COVID-19: systemic pathology and its implications for therapy
TL;DR: The physiological and pathological damage of SARS-CoV-2 to human respiratory system, immune system, blood circulation system, nervous system, motor system, urinary system, reproductive system and digestive system is summarized.
Journal ArticleDOI
The Interaction Between Pulmonary Fibrosis and COVID-19 and the Application of Related Anti-Fibrotic Drugs
TL;DR: The relevant mechanism pathways of COVID-19 and pulmonary fibrosis are summarized, the interrelationships and possible mechanisms are explored, and the value and risks are discussed, to provide reference for anti-fibrosis treatment for patients.
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