Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation
TL;DR: The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) was sequentially redefined during the past decades as mentioned in this paper and was recognized as a central mediator of inflammation bridging the innate and adaptive arms of the immune system.
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IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding
Sofija Sekulic Markovic,Marina Jovanovic,Nevena Gajovic,Milena Jurisevic,Nebojsa Arsenijevic,Milan Jovanović,Zeljko Mijailovic,Snezana Lukic,Nenad Zornic,Vladimir Vukicevic,Jasmina Stojanovic,Veljko Maric,Miodrag Jocic,Ivan Jovanović +13 more
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Emerging Human Coronavirus Infections (SARS, MERS, and COVID-19): Where They Are Leading Us.
TL;DR: All three SARS, MERS, and COVID-19 CoV epidemics are described in terms of their causal organisms, similarities and differences in their clinical symptoms, outcomes, immunology, and immunopathogenesis, and possible future therapeutic approaches.
Posted ContentDOI
An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19
TL;DR: In this paper, Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells.
Journal ArticleDOI
High-dimensional single-cell analysis reveals the immune characteristics of COVID-19.
Wen Shi,Wen Shi,Xiuxing Liu,Qiqi Cao,Pengjuan Ma,Wenqing Le,Lihui Xie,Jinguo Ye,Wen Wen,Hao Tang,Wenru Su,Yingfeng Zheng,Yingfeng Zheng,Yizhi Liu,Yizhi Liu +14 more
TL;DR: Interestingly, COVID-19 induces a dysregulation in the balance of monocyte populations by the expansion of the monocyte subsets, and this results represent a high-dimensional, single-cell profile of the peripheral immune response to SARS-CoV-2 infection.
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