Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
TL;DR: In this article , the effect of COVID-19 on the count, function and morphology of immune and blood cells and the role of these changes in the pathophysiology of the disease were discussed.
Journal ArticleDOI
The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
Sabina Sahanic,Judith Löffler-Ragg,Piotr Tymoszuk,Richard Hilbe,Egon Demetz,Rebecca K Masanetz,Markus Theurl,Johannes Holfeld,Can Gollmann-Tepeköylü,Alexandar Tzankov,Guenter Weiss,Martin Giera,Ivan Tancevski +12 more
TL;DR: In this article, the authors discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection and discuss different potential approaches to sustain the synthesis of 3PUFA-derived pro-resolving lipid mediators, including resolvins and lipoxins, which may critically aid in the prevention of acute lung injury and death from COVID-19.
Journal ArticleDOI
Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target.
Konstantinos Ntatsoulis,Theodoros Karampitsakos,Eliza Tsitoura,Elli-Anna Stylianaki,Alexios N Matralis,Argyrios Tzouvelekis,Katerina M. Antoniou,Vassilis Aidinis +7 more
TL;DR: In this paper, the authors discuss the similarities of COVID-19, ARDS and ILDs and suggest ATX as a possible pathologic link and a potential common therapeutic target.
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Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2.
TL;DR: In this paper, the nano-reformulation of the repurposed drugs for inhalation is proposed as a promising approach for targeted drug delivery to lungs, which can provide a stronger, more localized action, with reduced adverse effects.
Journal ArticleDOI
Neutrophil-Dependent Immunity During Pulmonary Infections and Inflammations.
Clement Yaw Effah,Emmanuel Kwateng Drokow,Clement Agboyibor,Lihua Ding,Sitian He,Shaohua Liu,Senyo Yao Akorli,Emmanuel Nuamah,Tongwen Sun,Xiaolei Zhou,Hong Liu,Zhiwei Xu,Feifei Feng,Yongjun Wu,Xiaoju Zhang +14 more
TL;DR: In this paper, a review aims at highlighting some of the developments in lung neutrophil-immunity by focusing on the functions and roles of CXC/CC chemokines and pattern recognition receptors during pulmonary inflammations.
References
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