Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Cardiovascular consequences of viral infections: from COVID to other viral diseases.
Heinz-Peter Schultheiss,Christian Baumeier,Heiko Pietsch,C.-Thomas Bock,C.-Thomas Bock,Wolfgang Poller,Felicitas Escher +6 more
TL;DR: A review of the current knowledge and available evidence on viral infections of the heart is presented in this paper, focusing on diagnostics, clinical relevance and cardiovascular consequences, pathophysiology, and current and novel treatment strategies.
Posted ContentDOI
Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children
Noam D. Beckmann,Phillip H. Comella,Esther Cheng,Lauren Lepow,Aviva G. Beckmann,Konstantinos Mouskas,Nicole W. Simons,Gabriel E. Hoffman,Nancy Francoeur,Diane Marie Del Valle,Gurpawan Kang,Emily Moya,Lillian Wilkins,Jessica Le Berichel,Christie Chang,Robert Marvin,Sharlene Calorossi,Alona Lansky,Laura Walker,Nancy Yi,Alex J. Yu,Matthew Harnett,Melody Eaton,Sandra Hatem,Hajra Jamal,Alara Akyatan,Alexandra Tabachnikova,Lora Liharska,Liam Cotter,Brian Fennessey,Akhil Vaid,Guillermo Barturen,Scott R. Tyler,Hardik Shah,Yinh-chih Wang,Shwetha Hara Sridhar,Juan C. Diaz Soto,Swaroop Bose,Kent Madrid,Ethan Ellis,Elyze Merzier,Konstantinos Vlachos,Nataly Fishman,Manying Tin,Melissa Smith,Hui Xie,Manishkumar Patel,Kimberly Argueta,Jocelyn Harris,Neha Karekar,Craig Batchelor,Jose Lacunza,Mahlet Yishak,Kevin Tuballes,Leisha Scott,Arvind Kumar,Suraj K. Jaladanki,Ryan Thompson,Evan Clark,Bojan Losic,Jun Zhu,Wenhui Wang,Andrew Kasarskis,Benjamin S. Glicksberg,Girish N. Nadkarni,Dusan Bogunovic,Cordelia Elaiho,Sandeep Gangadharan,George Ofori-Amanfo,Kasey Alesso-Carra,Kenan Onel,Karen M. Wilson,Carmen Argmann,Marta E. Alarcón-Riquelme,Thomas U. Marron,Adeeb Rahman,Seunghee Kim-Schulze,Sacha Gnjatic,Bruce D. Gelb,Miriam Merad,Robert Sebra,Eric E. Schadt,Alexander W. Charney +82 more
TL;DR: Findings suggest dysregulated cytotoxic lymphocyte response to SARS-Cov-2 infection in MIS-C is dysregulated.
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Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory programming and continual clearance of apoptotic cells
Douglas dos-Santos,Ana Carolina Guerta Salina,Tamara S Rodrigues,Marlon F. Rocha,Edismauro Garcia Freitas-Filho,Daniel L. Alzamora-Terrel,Mikhael Haruo Fernandes de Lima,D. C. Nascimento,Ícaro Maia Santos de Castro,Camila A. M. Silva,Juliana E Toller-Kawahisa,Amanda Becerra,Samuel L. Oliveira,Diego B. Caetite,Letícia Yamawaka de Almeida,Adriene Y. Ishimoto,Thais Martins de Lima,Ronaldo B. Martins,Flávio P. Veras,Natalia B. do Amaral,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria I. F. Lopes,Maira N. Benatti,Sabrina Setembre Batah,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Maria Auxiliadora Martins,Rodrigo Luppino Assad,Sérgio C. L. Almeida,Fabiola Reis de Oliveira,Eurico de Arruda Neto,Thiago M. Cunha,José C. Alves-Filho,Fernando Q. Cunha,Alexandre Todorovic Fabro,Helder I. Nakaya,Dario S. Zamboni,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Larissa D. Cunha +40 more
TL;DR: In this article, the authors show that engulfment of SARS-CoV2-infected apoptotic cells (AC) exacerbates inflammatory cytokine production, inhibits the expression of efferocytic receptors, and impairs continual efferocytetosis by macrophages.
Journal ArticleDOI
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Kami Pekayvaz,Alexander Leunig,Rainer Kaiser,Markus Joppich,Sophia Brambs,Aleksandar Janjic,Oliver Popp,Daniel Nixdorf,Valeria Fumagalli,Nora Schmidt,Vivien Polewka,Afra Anjum,Viktoria Knottenberg,Luke Eivers,Lucas E. Wange,Christoph Gold,Marieluise Kirchner,Maximilian Muenchhoff,Johannes C. Hellmuth,Clemens Scherer,Raquel Rubio-Acero,Tabea M. Eser,F. Deak,Kerstin Puchinger,Niklas Kuhl,Andrea Linder,Kathrin Saar,L. Tomás,Christian Schulz,Andreas Wieser,Wolfgang Enard,Inge Kroidl,Christof Geldmacher,Michael von Bergwelt-Baildon,Oliver T. Keppler,Mathias Munschauer,Matteo Iannacone,Ralf Zimmer,Philipp Mertins,Norbert Hubner,Michael Hoelscher,Steffen Massberg,Konstantin Stark,Leo Nicolai +43 more
TL;DR: In this article , the authors combine a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment.
Journal ArticleDOI
The importance of physical activity in management of type 2 diabetes and COVID-19.
Samuel Seidu,Kamlesh Khunti,Thomas Yates,Abdullah Almaqhawi,Melanie J. Davies,Jack A. Sargeant +5 more
TL;DR: In this paper, the authors evaluate the effectiveness of physical activity in people with type 2 diabetes and COVID-19 and conclude that home-based physical exercise may be an essential component in future physical activity recommendations given the current COVID19 pandemic and the need for social distancing.
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