Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
Citations
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Mucosal immune responses in COVID19 - a living review
TL;DR: In this article, the authors compare the disease processes between the lungs and gastrointestinal tract, and what might drive these different responses. And they also consider the effect that microbial species may play on infection and subsequent immune responses.
Journal ArticleDOI
A 21st Century Evil: Immunopathology and New Therapies of COVID-19.
Taylon Felipe Silva,Fernanda Tomiotto-Pellissier,Raquel Arruda Sanfelice,Manoela Daiele Gonçalves,Bruna Taciane da Silva Bortoleti,Mariana Barbosa Detoni,Ana Carolina Jacob Rodrigues,Amanda Cristina Machado Carloto,Virginia Marcia Concato,Elaine da Silva Siqueira,Idessania Nazareth Costa,Wander Rogério Pavanelli,Ivete Conchon-Costa,Milena Menegazzo Miranda-Sapla +13 more
TL;DR: The interaction between SARS-CoV-2 and the patient’s host immune system during infection is addressed, in addition to discussing the main immunopathological mechanisms involved in the development of the disease and potential new therapeutic approaches.
Journal ArticleDOI
COVID-19 disease and immune dysregulation
TL;DR: The SARS-CoV-2 virus has complex and divergent immune alterations in differing hosts and over disease evolution as mentioned in this paper , and the potential relevance from acute infection to a multisystem inflammatory syndrome commonly seen in children.
Journal ArticleDOI
Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 Patients
Xiaorui Wang,Han Bai,Junpeng Ma,Hongyu Qi,Qiqi Zeng,Fang Hu,Tao Jiang,Weikang Mao,Yang Zhao,Xiaobei Chen,Xin Qi,MengYang Li,Jiao Xu,Jingcan Hao,Yankui Wang,Xi Ding,Yuanrui Liu,Chao Fang,Changli Ge,Dong Li,Ke Hu,Xianwen Ren,Baojun Zhang,Ning Zhang,Bingyin Shi,Chengsheng Zhang +25 more
TL;DR: 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 are identified using scRNA-seq technology coupled with a deep and comprehensive analysis of unique cell surface markers and differentially expressed genes.
Journal ArticleDOI
Single cell sequencing unraveling genetic basis of severe COVID19 in obesity.
Antoine Fakhry AbdelMassih,Raghda Fouda,Raghda Fouda,Aya Kamel,Fady Mishriky,Habiba Allah Ismail,Layla El Qadi,Lauris Malak,Maram Mohamed,Mariem Arsanyous,Maysa Hazem,Miral El-Husseiny,Mirette Ashraf,Nada Hafez,Nada AlShehry,Nadine El-Husseiny,Nora AbdelRaouf,Noura Shebl,Nouran Hafez,Nourhan Youssef,Peter Afdal,Rafeef Hozaien,Rahma Menshawey,Rana Saeed,Reem Yasser,Shereen Hesham,Wesam Zakarriah,Shahenda Khattab,Yasmine Elammary,Jianping Ye +29 more
TL;DR: The use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one is underlined.
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