Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
Citations
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Innate immunological pathways in COVID-19 pathogenesis
TL;DR: The emerging understanding of how SARS-CoV-2 and host-derived molecules activate specific pattern recognition receptors to elicit protective interferon responses and pathological cytokine responses is discussed, with particular focus on acute infection of the lung and lung pathophysiology in critical COVID-19.
Journal ArticleDOI
KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Jing Li,M. Zaslavsky,Yapeng Su,Jing Guo,Michael J. Sikora,Vincent van Unen,Asbjørn Christophersen,S. H. Chiou,Liang Chen,Jiefu Li,Xuhuai Ji,Julie Wilhelmy,Alana McSween,Brad A. Palanski,Venkata Vamsee Aditya Mallajosyula,Nathan A. Bracey,Gopal Krishna R. Dhondalay,Kartik Bhamidipati,Joy A. Pai,Lucas Kipp,Jeffrey Dunn,Stephen L. Hauser,Jorge R. Oksenberg,Ansuman T. Satpathy,William H. Robinson,Cornelia L. Dekker,Lars M. Steinmetz,Chaitan Khosla,Paul J. Utz,Ludvig M. Sollid,Yueh-hsiu Chien,James R. Heath,Nielsen Fernandez-Becker,Kari C. Nadeau,Naresha Saligrama,Mark M. Davis +35 more
TL;DR: It is found that CD8+ T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49+CD8+ regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases.
Journal ArticleDOI
Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
TL;DR: In this paper, the authors discuss how COVID-19 may interact with the peripheral nervous system to cause pain in the early and late stages of the disease and the implications of this potential neurotropism.
Journal ArticleDOI
SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings.
Phoebe C M Williams,Annaleise R Howard-Jones,Peter Hsu,Pamela Palasanthiran,Paul Gray,Brendan McMullan,Philip N Britton,Adam W. Bartlett,Adam W. Bartlett +8 more
TL;DR: Overall, children appear to be less frequently infected by, and affected by, SARS-CoV-2 virus and the clinical disease COVID-19, including the spectrum of disease in children, the role of children in virus transmission, and host-virus factors that underpin the unique aspects of Sars-Cov-2 pathogenicity in children.
Journal ArticleDOI
Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19.
Jang Hyun Park,Heung Kyu Lee +1 more
TL;DR: Re-analyzed published scRNA-seq data of COVID-19 patient bronchoalveolar lavage fluid to further classify and compare immunological features according to the patient’s disease severity and suggested that severe CO VID-19 symptoms may be determined by differential expression of glucocorticoid receptors and neutrophils.
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