Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.
TL;DR: The potential roles that NSAIDs and PGs may play during SARS‐CoV‐2 infection and the development and progression of COVID‐19 are surveyed.
Journal ArticleDOI
The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences.
Tayrine Ordonio Filgueira,Angela Castoldi,Lucas Eduardo Rodrigues Santos,Geraldo José de Amorim,Matheus Santos de Sousa Fernandes,Weydyson de Lima do Nascimento Anastácio,Eduardo Zapaterra Campos,Tony Meireles Santos,Fabrício Oliveira Souto +8 more
TL;DR: In this article, the effects of physical activity in physical fitness, immune defense, and its contribution to mitigate the severe inflammatory response mediated by SARS-CoV-2 infection is discussed.
Journal ArticleDOI
Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia
Nick P. Goplen,Yue Wu,Youngmin Son,Chaofan Li,Zheng Wang,In Su Cheon,Li Jiang,Bibo Zhu,Katayoun Ayasoufi,Eduardo N. Chini,Aaron J. Johnson,Robert Vassallo,Andrew H. Limper,Nu Zhang,Jie Sun +14 more
TL;DR: It is reported that influenza viral pneumonia leads to chronic nonresolving lung pathology and exacerbated accumulation of CD8+ tissue-resident memory T cells (TRM) in the respiratory tract of aged hosts.
Posted ContentDOI
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway
TL;DR: In this article, the authors investigated direct inflammatory functions of major structural proteins of SARS-CoV-2 and found that spike (S) protein potently induces inflammatory cytokines and chemokines including IL-6, IL-1s, TNFa, CXCL1, CCL2, but not IFNs in human and mouse macrophages.
Posted ContentDOI
A neutrophil activation signature predicts critical illness and mortality in COVID-19.
Matthew L Meizlish,Alexander B Pine,Jason Bishai,George Goshua,Emily R. Nadelmann,Michael Simonov,C-Hong Chang,Hanming Zhang,Marcus Shallow,Parveen Bahel,Kent A. Owusu,Yu Yamamoto,Tanima Arora,Deepak Atri,Amisha Patel,Rana Gbyli,Jennifer M. Kwan,Christine Won,Charles S. Dela Cruz,Christina Price,Jonathan L. Koff,Brett King,Henry M. Rinder,F. Perry Wilson,John Hwa,Stephanie Halene,William Damsky,David van Dijk,Alfred Ian Lee,Hyung J. Chun +29 more
TL;DR: An essential role for neutrophil activation in the pathogenesis of severe COVID-19 is defined and molecular neutrophIL markers that distinguish patients at risk of future clinical decompensation are identified.
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