Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19.
Dong-Min Kim,Yuri Kim,Yuri Kim,Jun-Won Seo,Jooyeon Lee,Uni Park,Na Young Ha,Na Young Ha,Jaemoon Koh,Hyoree Park,Jaewon Lee,Hyo-Jin Ro,Na Ra Yun,Da Young Kim,Sung Ho Yoon,Yong Sub Na,Do Sik Moon,Sung-Chul Lim,Choon-Mee Kim,Kyeongseok Jeon,Jun-Gu Kang,Na-Yoon Jang,Hyeongseok Jeong,Jungok Kim,Shinhyea Cheon,Kyung Mok Sohn,Jae Youg Moon,Sungmin Kym,Seung Ro Han,Myung-Shin Lee,Hyun Je Kim,Woong-Yang Park,Ji Yeob Choi,Hyun Woo Shin,Hyeyoung Kim,Chung-Hyun Cho,Yoon Kyung Jeon,Yeon Sook Kim,Nam Hyuk Cho +38 more
TL;DR: In this article, the authors show that critical CoV-2 infection is associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases, and confirm increased T helper (Th)2-biased adaptive immune responses, accompanying overt complement activation, in the critical group.
Posted ContentDOI
Comparative study of a 3CLpro inhibitor and remdesivir against both major SARS-CoV-2 clades in human airway models
Maren de Vries,Adil Mohamed,Rachel A Prescott,Ana M. Valero-Jimenez,Ludovic Desvignes,Ludovic Desvignes,Claire M. Steppan,Joseph C. Devlin,Ellie Ivanova,Alberto Herrera,Austin Schinlever,Paige Loose,Kelly V. Ruggles,Sergei B. Koralov,Annaliesa S. Anderson,Joseph John Binder,Meike Dittmann +16 more
TL;DR: In vitro evidence for the potential of PF-00835231 as an effective antiviral for SARS-CoV-2 is provided, concerns from non-human in vitro models are addressed, and further studies with this compound are supported.
Journal ArticleDOI
HIF-1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID-19 Pathogenesis.
TL;DR: In this paper, the authors discuss hypoxia's potential role in the pathogenesis of the maladaptive immune reaction against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Journal ArticleDOI
Obesity and its impact on COVID-19.
Angélica J M de Leeuw,Maureen A M Oude Luttikhuis,Annemarijn C Wellen,Christine Müller,Cornelis F. Calkhoven +4 more
TL;DR: In this paper, the authors reviewed literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and discussed the involvement of hyperactivation of the renin-angiotensin-aldosterone system.
Journal ArticleDOI
Neutrophil Extracellular Traps Contribute to COVID-19 Hyperinflammation and Humoral Autoimmunity.
Jiram Torres-Ruiz,Abdiel Absalón-Aguilar,Miroslava Nuñez-Aguirre,Alfredo Pérez-Fragoso,Daniel Alberto Carrillo-Vázquez,José L. Maravillas-Montero,Nancy R. Mejía-Domínguez,Luis Llorente,Beatriz Alcalá-Carmona,Jaquelin Lira-Luna,Carlos A. Núñez-Álvarez,Guillermo Juárez-Vega,David E. Meza-Sánchez,Thierry Hernández-Gilsoul,Miguel Tapia-Rodríguez,Diana Gómez-Martín +15 more
TL;DR: In this paper, the role of COVID-19 NETs as inducers of pro-inflammatory and autoimmune responses was revealed, showing that deficient degradation capacity of NETs may contribute to the accumulation of these structures.
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