Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
Citations
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Divergent early antibody responses define COVID-19 disease trajectories
Saborni Chakraborty,Joseph C. Gonzalez,Benjamin L. Sievers,Vamsee Mallajosyula,Megha Dubey,Yik-Ling Bowie Cheng,Kim Q.t. Tran,Srijoni Chakraborty,Arianna G. Cassidy,Steven T. Chen,Aanika Sinnott,Terri Gelbart,Yarden Golan,Mary Prahl,Upinder Singh,Seunghee Kim-Schulze,Robert Sherwood,Sheng Zhang,Thomas U. Marron,Sacha Gnjatic,Stephanie L. Gaw,Kari C. Nadeau,Miriam Merad,Prasanna Jagannathan,Gene S. Tan,Gene S. Tan,Taia T. Wang +26 more
TL;DR: The authors found that distinct features of IgG Fab and Fc domain structures were present within three days of a positive test that predicted two separate disease trajectories in a prospective cohort of patients with COVID-19.
Journal ArticleDOI
Single Cell Transcriptomic Re-analysis of Immune Cells in Bronchoalveolar Lavage Fluids Reveals the Correlation of B Cell Characteristics and Disease Severity of Patients with SARS-CoV-2 Infection
TL;DR: In this article, the authors reanalyzed scRNA-seq data of cells from bronchoalveolar lavage fluids of patients with severe acute respiratory syndrome coronavirus 2 with mild and severe symptoms, focusing on Ab-producing cells.
Journal ArticleDOI
Murine-β-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2
TL;DR: A review of the neuroimmunopathological processes in murine CoVs is presented in this article, where the authors make references to the neuro-immune axis and neuro-invasive potential of SARSCoV and SARS-CoV2, as well as the prototypic H-coV strains in human brains.
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Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
Garry Dolton,Cristina Rius,Samiul Hasan,Aaron Wall,Barbara Szomolay,Enas M. Behiry,Thomas Whalley,Joel Southgate,Anna Fuller,Théo Morin,Katie Topley,Li Rong Tan,Philip J. R. Goulder,Owen Brad Spiller,Pierre J. Rizkallah,Lucy C. Jones,Lucy C. Jones,Thomas R. Connor,Andrew K. Sewell +18 more
TL;DR: In this article, the authors studied the prevalent CD8 killer T-cell response mounted against SARS-CoV-2 Spike 269-277 epitope YLQPRTFLL via the most frequent Human Leukocyte Antigen (HLA) class I worldwide, HLA A*02.
Posted ContentDOI
Context-aware deconvolution of cell-cell communication with Tensor-cell2cell
Erick Armingol,Hratch M. Baghdassarian,Cameron Martino,Cameron Martino,Araceli Perez-Lopez,Rob Knight,Nathan E. Lewis +6 more
TL;DR: Tensor-cell2cell as mentioned in this paper is an unsupervised method using tensor decomposition to decipher context-driven intercellular communication by simultaneously accounting for multiple stages, states, or locations of the cells.
References
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