Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?
TL;DR: In severe COVID-19, the levels of iron (Fe), copper (Cu), zinc (Zn), and selenium (Se) do not only regulate host immune responses but modify the viral genome, as well as discussed by the authors .
Posted ContentDOI
CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection
Abigail Vanderheiden,Abigail Vanderheiden,James W. Thomas,Allison Soung,Meredith E. Davis-Gardner,Meredith E. Davis-Gardner,Katharine Floyd,Katharine Floyd,Jin F,Jin F,Cowan Da,Cowan Da,Kathryn L. Pellegrini,Kathryn L. Pellegrini,Adrian Creanga,Amarendra Pegu,Alexandrine Derrien-Colemyn,Pei Yong Shi,Arash Grakoui,Arash Grakoui,Robyn S. Klein,Steven E. Bosinger,Steven E. Bosinger,Jacob E. Kohlmeier,Vineet D. Menachery,Mehul S. Suthar +25 more
TL;DR: In this paper, a mouse model of SARS-CoV-2 infection was characterized and it was shown that early CCR2-dependent infiltration of monocytes restricts viral burden in the lung.
Journal ArticleDOI
Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing
TL;DR: In the older and oldest age groups and in people with co-morbidities such as diabetes, heart disease and obesity, COVID-19 endangers lives, has disrupted normal life, changed the way medicine is practised and is likely to alter our world for the foreseeable future as discussed by the authors .
Journal ArticleDOI
Endothelial cell, myeloid, and adaptive immune responses in SARS-CoV-2 infection.
TL;DR: In this article, the authors reviewed endothelial cell responses in inflammation and infection due to SARS-CoV-2 together with phenotypic and functional alterations of monocytes, T and B lymphocytes with which they interact and surmise that endothelial cells function as an integrative and active platform for the various cells recruited.
Journal ArticleDOI
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations.
Luiz Gustavo de Almeida Chuffa,Paula Paccielli Freire,Jeferson dos Santos Souza,Mariana Costa de Mello,Mario de Oliveira Neto,Robson Francisco Carvalho +5 more
TL;DR: In this article, the authors investigated the whole transcriptome from the Genotype-Tissue Expression (GTEx) database to explore differentially expressed genes translated into proteins interacting with viral proteins during aging.
References
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