Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Geraldine Nouailles,Emanuel Wyler,Peter Pennitz,Dylan Postmus,Daria Vladimirova,Julia Kazmierski,Fabian Pott,Kristina Dietert,Michael Muelleder,V. M. Farztdinov,Benedikt Obermayer,Sandra-Maria Wienhold,Sandro Andreotti,Thomas Hoefler,Birgit Sawitzki,Christian Drosten,Leif E. Sander,Norbert Suttorp,Markus Ralser,Markus Ralser,Dieter Beule,Achim D. Gruber,Christine Goffinet,Markus Landthaler,Markus Landthaler,Jakob Trimpert,Martin Witzenrath +26 more
TL;DR: In this article, a detailed longitudinal analysis of systemic and pulmonary cellular responses, and corroborate it with datasets from COVID-19 patients, was conducted using Syrian hamsters as a model for moderate CoV-2 infection.
Journal ArticleDOI
COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?
TL;DR: In this article, the authors discuss how the comparison of clinical features, immunologic parameters and therapeutic response data between Macrophage activation syndrome (MAS) and hyperinflammation in COVID-19 patients can provide new insight into the pathophysiology of CSS.
Journal ArticleDOI
Age-Related Differences in Immunological Responses to SARS-CoV-2.
Lydia Su Yin Wong,Evelyn Xiu Ling Loo,Evelyn Xiu Ling Loo,Alicia Yi Hui Kang,Hui Xing Lau,Paul A. Tambyah,Elizabeth Huiwen Tham,Elizabeth Huiwen Tham,Elizabeth Huiwen Tham +8 more
TL;DR: Understanding the mechanisms through which pediatric patients are protected from severe novel coronaviruses infections will provide critical clues to the pathophysiology of COVID-19 infection and inform future therapeutic and prophylactic interventions.
Journal ArticleDOI
Tissue resident memory T cells in the respiratory tract
Ming Z. M. Zheng,Linda M. Wakim +1 more
TL;DR: In this paper, the authors discuss factors that influence respiratory tract tissue-resident memory (Trm) development, longevity, and immune surveillance and explore vaccination regimes that harness these cells, such approaches represent exciting new strategies that may be utilized to tackle the next global pandemic.
Journal ArticleDOI
Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets.
TL;DR: This work hypothesizes that resident AMs are terminally differentiated cells with low responsiveness and limited plasticity, while recruited, monocyte-derived AMS are initially highly immunoreactive but more plastic, able to change their function in response to environmental cues.
References
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