Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
Citations
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An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19.
TL;DR: Based on the unique affinity between dermatan sulfate and autoantigens, the authors identified 348 proteins from human lung A549 cells, of which 198 are known targets of autoantibodies.
Journal ArticleDOI
Insights into SARS-CoV-2 Persistence and Its Relevance.
TL;DR: A living literature review of the mechanism of persistent viral shedding, reinfection, and the post-acute sequalae of SARS-CoV-2 infection (PASC) is presented to guide and direct future basic science and clinical research priorities.
Journal ArticleDOI
Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach.
Sinead M. O’Donovan,Ali S Imami,Hunter M. Eby,Nicholas D. Henkel,Justin F. Creeden,Sophie Asah,Xiaolu Zhang,Xiaojun Wu,Rawan Alnafisah,R. Travis Taylor,James Reigle,James Reigle,Alexander William Thorman,Behrouz Shamsaei,Jarek Meller,Robert E. McCullumsmith +15 more
TL;DR: In this paper, a bioinformatics workflow was deployed to identify candidate drugs for the treatment of COVID-19 pandemic caused by the novel SARS-CoV-2.
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Non-Coding RNAs in COVID-19: Emerging Insights and Current Questions.
TL;DR: In this article, the authors discuss and evaluate evidence demonstrating the involvement of short and long ncRNAs in severe acute respiratory syndrome coronavirus disease 2019 (COVID-19) and use this information to propose hypotheses for future mechanistic and clinical studies.
Journal ArticleDOI
Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19 Associated Coagulopathies.
TL;DR: In this paper, a coagulation-focused transcriptome analysis of in-vitro infected primary respiratory epithelial cells, patient-derived bronchial alveolar lavage cells, and circulating immune cells during SARS-CoV-2 infection was performed.
References
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