Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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The COVID-19 infection in children and its association with the immune system, prenatal stress, and neurological complications
Suliman Khan,Rabeea Siddique,Xiao Hao,Yueting Lin,Yuxin Liu,Xiaoyan Wang,Linlin Hua,Ghulam Nabi +7 more
TL;DR: This review discusses viral transmission, transport to the brain, the associated prenatal stress, and neurological and/or immunological complications in children.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this paper , the authors found that both B and T lymphocytes were susceptible to SARS-CoV-2 infection in vitro, accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.
Journal ArticleDOI
Cytokine release syndrome and the prospects for immunotherapy with COVID-19. Part 2: The role of interleukin 1.
TL;DR: Preliminary evidence indicates that anakinra and canakinumab, drugs that block the action of IL-1 and have a good safety profile, improve the outcomes of patients with COVID-19 cytokine release syndrome.
Journal ArticleDOI
Non-genetic Heterogeneity of Macrophages in Diseases-A Medical Perspective.
TL;DR: Various features of macrophage heterogeneity in five main categories of human diseases: infectious, inflammatory, metabolic, age-related, and neoplastic disorders are discussed and a comprehensive overview is proposed to help in establishing future macrophages-targeted therapies.
Posted ContentDOI
Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients
Jaana Westmeier,Krystallenia Paniskaki,Zehra Karaköse,Tanja Werner,Kathrin Sutter,Sebastian Dolff,Marvin Overbeck,Andreas Limmer,Jia Liu,Xin Zheng,Thorsten Brenner,Marc M. Berger,Oliver Witzke,Mirko Trilling,Mengji Lu,Dongliang Yang,Nina Babel,Nina Babel,Timm H. Westhoff,Ulf Dittmer,Gennadiy Zelinskyy +20 more
TL;DR: COVID-19 patients with a mild disease course were analyzed for the differentiation status and cytotoxic profile of CD8+ T cells and it was found that elderly patients have impaired cellular immunity against SARS-CoV-2.
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