Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.Abstract:
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.read more
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Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?
F. Costanza,Andrea Amerio,Andrea Aguglia,Gianluca Serafini,Massimo Amore,Roland Hasler,Julia Ambrosetti,Guido Bondolfi,Gaia Sampogna,Isabella Berardelli,A. Fiorillo,Marcella Pompili,Khoa D. Nguyen +12 more
TL;DR: In this article , the authors provide a summary of current knowledge on the molecular and cellular mechanisms of COVID-19-associated hyper/neuroinflammation with focus on their relevance to the inflammatory hypothesis of suicide development.
Posted ContentDOI
deCS: A tool for systematic cell type annotations of single-cell RNA sequencing data among human tissues
TL;DR: Wang et al. as mentioned in this paper presented deCS (decoding Cell type-Specificity), an automatic cell type annotation method based on a comprehensive collection of human cell type expression profiles or a list of marker genes.
Journal ArticleDOI
Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy.
TL;DR: In this article, the ΔORF6 mutant of SARS-CoV was used as a surrogate for SARS CoV-2, since both lack the moiety responsible for interferon antagonistic effects.
Journal ArticleDOI
Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients
TL;DR: In this article , the authors compared the purinergic profile of the total leukocyte population and evaluated the levels of these soluble biomolecules in the blood, and their correlation with coagulation components in COVID-19 patients, in comparison to healthy people or non-COVID-2019 patients.
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A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options
Esen Sefik,Ben Israelow,Jun Zhao,Rihao Qu,Eric Song,Haris Mirza,Eleanna Kaffe,Stephanie Halene,Eric Meffre,Yuval Kluger,Michel C. Nussenzweig,Craig B. Wilen,Akiko Iwasaki,Richard A. Flavell +13 more
TL;DR: In this paper, the authors presented a comprehensively humanized mouse COVID-19 model that faithfully recapitulates the innate and adaptive human immune responses during infection with SARS-CoV-2 by adapting recombinant adeno-associated virus (AAV)-driven gene therapy to deliver human ACE2 to the lungs 1 of MISTRG6 mice.
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