C
Chris Haley
Researcher at University of Edinburgh
Publications - 427
Citations - 26040
Chris Haley is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Quantitative trait locus & Population. The author has an hindex of 71, co-authored 410 publications receiving 23592 citations. Previous affiliations of Chris Haley include Medical Research Council & The Roslin Institute.
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Journal ArticleDOI
A simple regression method for mapping quantitative trait loci in line crosses using flanking markers.
Chris Haley,Sara Knott +1 more
TL;DR: Methods for mapping QTL based on multiple regression which can be applied using any general statistical package are developed and it is shown that these regression methods produce very similar results to those obtained using maximum likelihood.
Journal ArticleDOI
Modulation of genetic associations with serum urate levels by body-mass-index in humans
Jennifer E. Huffman,Eva Albrecht,Alexander Teumer,Massimo Mangino,Karen Kapur,Toby Johnson,Z. Kutalik,Nicola Pirastu,Giorgio Pistis,Lorna M. Lopez,Toomas Haller,Perttu Salo,Anuj Goel,Man Li,Toshiko Tanaka,Abbas Dehghan,Daniela Ruggiero,Giovanni Malerba,Albert V. Smith,Ilja M. Nolte,Laura Portas,Amanda Phipps-Green,Lora Boteva,Pau Navarro,Åsa Johansson,Andrew A. Hicks,Ozren Polasek,Tõnu Esko,John F. Peden,Sarah E. Harris,Federico Murgia,Sarah H. Wild,Albert Tenesa,Adrienne Tin,Evelin Mihailov,Anne Grotevendt,Gauti Kjartan Gislason,Josef Coresh,Pio D'Adamo,Sheila Ulivi,Peter Vollenweider,Gérard Waeber,Susan Campbell,Ivana Kolcic,Krista Fisher,Margus Viigimaa,Jeffrey Metter,Corrado Masciullo,Elisabetta Trabetti,Cristina Bombieri,Rossella Sorice,Angela Doering,Eva Reischl,Konstantin Strauch,Albert Hofman,André G. Uitterlinden,Melanie Waldenberger,H-Erich Wichmann,Gail Davies,Alan J. Gow,Nicola Dalbeth,Lisa K. Stamp,Johannes H. Smit,Mirna Kirin,Ramaiah Nagaraja,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Susan M. Farrington,Evropi Theodoratou,Antti Jula,Veikko Salomaa,Cinzia Sala,Christian Hengstenberg,Michel Burnier,R Maegi,Norman Klopp,Stefan Kloiber,Sabine Schipf,Samuli Ripatti,Stefano Cabras,Nicole Soranzo,Georg Homuth,Teresa Nutile,Patricia B. Munroe,Nicholas D. Hastie,Harry Campbell,Igor Rudan,Claudia P. Cabrera,Chris Haley,Oscar H. Franco,Tony R. Merriman,Vilmundur Gudnason,Mario Pirastu,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Harold Snieder,Andres Metspalu,Marina Ciullo,Peter P. Pramstaller,Cornelia M. van Duijn,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Malcolm G. Dunlop,James F. Wilson,Paolo Gasparini,Ulf Gyllensten,Tim D. Spector,Alan F. Wright,Caroline Hayward,Hugh Watkins,Markus Perola,Murielle Bochud,W. H. Linda Kao,Mark J. Caulfield,Daniela Toniolo,Henry Voelzke,Christian Gieger,Anna Koettgen,Veronique Vitart +120 more
TL;DR: Interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, and regression-type analyses in a non BMI-stratified overall sample suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum.
Journal ArticleDOI
Genetic mechanisms of critical illness in Covid-19.
Erola Pairo-Castineira,Erola Pairo-Castineira,Sara Clohisey,Lucija Klaric,Andrew D. Bretherick,Konrad Rawlik,Dorota Pasko,Susan P. Walker,Nicholas J. Parkinson,Max Head Fourman,Clark D Russell,James J Furniss,Anne Richmond,E. Gountouna,Nicola Wrobel,David A Harrison,B. Wang,Yang Wu,A. Meynert,Fiona Griffiths,Wilna Oosthuyzen,Athanasios Kousathanas,Loukas Moutsianas,Z. Yang,R. Zhai,Canbin Zheng,Graeme R. Grimes,Rupert Beale,Jonathan E Millar,Barbara Shih,Seán Keating,Marie Zechner,Chris Haley,David J. Porteous,Caroline Hayward,Jian Yang,Julian C. Knight,Charlotte Summers,Manu Shankar-Hari,Manu Shankar-Hari,Paul Klenerman,Lance Turtle,Antonia Ho,S. C. Moore,Charles J. Hinds,P. Horby,Alistair Nichol,Alistair Nichol,Alistair Nichol,David M. Maslove,Lowell Ling,Daniel F. McAuley,Hugh Montgomery,Timothy S. Walsh,Alexandre C. Pereira,Alessandra Renieri,C. Ponting,J. Meikle,P. Finernan,E. Mcmaster,E. Mcmaster,Andy Law,J. K. Baillie,T. Paterson,T. Wackett,Robert C. Armstrong,Robert C. Armstrong,R. Clark,A. Coutts,L. Donnelly,Tamara Gilchrist,K. Hafezi,K. Hafezi,L. Macgillivray,L. Macgillivray,Alan MacLean,Sarah McCafferty,Kirstie Morrice,J. Weaver,C. Boz,C. Boz,A. Golightly,Minghong Ward,H. Mal,H. Szoor-McElhinney,Anthony Brown,Ross Hendry,A. Stenhouse,L. Cullum,D. Law,S. Law,R. Law,Maaike C. Swets,N. Day,F. Taneski,Emma L. Duncan,David Collier,S. Wood,A. Zak,C. Borra,M. Matharu,P. May,Z. Alldis,O. Mitchelmore,R. Bowles,A. Easthope,F. Bibi,I. Lancoma-Malcolm,J. Gurasashvili,J. Pheby,J. Shiel,M. Bolton,Minal Patel,M. Taylor,O. Zongo,P. Ebano,P. Harding,R. Astin-Chamberlain,Y. Choudhury,Anna Cox,D. Kallon,M. Burton,R. Hall,S. Blowes,Z. Prime,J. Biddle,O. Prysyazhna,T. Newman,C. Tierney,J. Kassam,Marlies Ostermann,S. Campos,A. Bociek,R. Lim,N. Grau,T. O. Jones,C. Whitton,M. Marotti,Gill Arbane,S. Bonner,K. Hugill,J. Reid,Ingeborg Welters,V. Waugh,Katherine Williams,D. Shaw,J. F. Roman,M. L. Martinez,Elizabeth M. Johnson,A. Waite,B. Johnston,D. Hamilton,S. Mulla,Mark J. W. McPhail,John A. S. Smith,L. Barclay,D. Hope,Corrienne McCulloch,L. McQuillan,S. Clark,J. Singleton,K. Priestley,N. Rea,M. Callaghan,R. Campbell,G. Andrew,L. Marshall,Stuart McKechnie,P. Hutton,A. Bashyal,N. Davidson,P. Polgarova,K. Stroud,N. Pathan,K. Elston,Sutapa Agrawal,Ceri Battle,L. Newey,Tim Rees,R. Harford,E. Brinkworth,Martin S. Williams,C. Murphy,I. M. S. White,M. Croft,N. Bandla,M. Gellamucho,J. Tomlinson,H. Turner,Michael Davies,A. Quinn,I. Hussain,Christopher C. Thompson,H. Parker,R. Bradley,R. Griffiths,J. Scriven,A. Nilsson,Matthew G.D. Bates,J. Dasgin,Janusz Gill,Alex Puxty,S. Cathcart,D. Salutous,L. Turner,K. Duffy,K. Puxty,Anna Maria Joseph,R. Herdman-Grant,R. Simms,A. Swain,A. Naranjo,R. Crowe,K. Sollesta,A. Loveridge,D. Baptista,E. Morino,M. Davey,D. Golden,J. Jones,J. Moreno Cuesta,A. Haldeos,D. Bakthavatsalam,Royce P Vincent,M. Elhassan,K. Xavier,Anand K. Ganesan,D. Purohit,M. Abdelrazik,J.M. Morgan,L. Akeroyd,S. Bano,T. Lawton,D. Warren,M. Bromley,K. Sellick,L. Gurr,B. Wilkinson,V. Nagarajan,P. Szedlak,Jason Cupitt,E. Stoddard,L. Benham,S. Preston,Shondipon Laha,N. Slawson,Z. Bradshaw,Jamie Brown,M. Caswell,S. Melling,P. Bamford,M. Faulkner,K. Cawley,H. Jeffrey,E. London,H. Sainsbury,I. Nagra,F. Nasir,C. Dunmore,R. L. Jones,A. Abraheem,M. Al-Moasseb,R. Girach,G. Padden,Josephine M. Egan,C. Brantwood,P. Alexander,J. Bradley-Potts,Susan Allen,Timothy Felton,S. Manna,S. Farnell-Ward,S. Leaver,J. Queiroz,E. Maccacari,D. Dawson,C. C. Delgado,R. P. Saluzzio,O. Ezeobu,L. Ding,C. Sicat,R. Kanu,G. Durrant,J. Texeira,Abby Harrison,T. Samakomva,H. Willis,B. Hopkins,L. Thrasyvoulou,M. Jackson,A. Zaki,C. Tibke,Suzanne Bennett,W. Woodyatt,A. Kent,E. Goodwin,C. Brandwood,Lee B. Smith,Kevin Rooney,Neil C. Thomson,N. Rodden,Ellen C Hughes,D. McGlynn,C. Clark,P. Clark,Laurent Abel,R. Sundaram,L. Gemmell,M. Brett,J. Hornsby,P. MacGoey,R. Price,B. Digby,P. O'Neil,P. McConnell,Paul Henderson,Seton J Henderson,M. Sim,S. Kennedy-Hay,C. McParland,L. Rooney,N. Baxter,D. Pogson,S. Rose,Z. Daly,L. Brimfield,Mandeep Phull,M. Hussain,T. Pogreban,L. Rosaroso,E. Salciute,L. Grauslyte,David Brealey,Eamon P. Raith,N. MacCallum,G. Bercades,I. Hass,D. Smyth,A. Reyes,G. Martir,I. D. Clement,K. Webster,C. Hays,A. Gulati,Luke Hodgson,M. Margarson,Refujia Gomez,Y. Baird,Y. Thirlwall,L. Folkes,A. Butler,E. Meadows,Shona C Moore,D. Raynard,Helen C. Fox,L. Riddles,K. King,S. Kimber,G. Hobden,Anne Marie McCarthy,V. Cannons,I. Balagosa,I. Chadbourn,A. Gardner,D. Horner,D. McLaughlanv,B. Charles,N. Proudfoot,T. Marsden,L. McMorrow,B. Blackledge,J. Pendlebury,Alison G. Harvey,E. Apetri,C. Basikolo,L. Catlow,R. Doonan,K. Knowles,S. Lee,David A. Lomas,C. Lyons,Joseph Perez,M. Poulaka,M. Slaughter,K. Slevin,V. Thomas,David W. Walker,Jennifer R. Harris,A. Drummond,R. Tully,J. Dearden,J. Philbin,S. Munt,C. Rishton,G. O'Connor,M. Mulcahy,E. Dobson,J. Cuttler,M. Edward,Jill M. Norris,K. Hanson,Alexis Poole,Alistair Rose,B. Sloan,S. Buckley,H. Brooke,E. Smithson,R. Charlesworth,R. Sandhu,M. Thirumaran,V. Wagstaff,J. C. Suarez,Agilan Kaliappan,M. Vertue,Andrew G. Nicholson,J. Riches,A. Solesbury,L. Kittridge,M. Forsey,G. Maloney,John B. Cole,R. Davies,H. Hill,E L Thomas,A. Williams,D. Duffin,B. Player,Jayachandran Radhakrishnan,Spencer B. Gibson,A. Lyle,F. McNeela,Brijesh V. Patel,M. Gummadi,G. Sloane,N. Dormand,S. Salmi,Z. Farzad,D. Cristiano,K. Liyanage,V. Thwaites,M. Varghese,M. Meredith,Gordon B. Mills,J. Willson,K. Harrington,B. Lenagh,K. Cawthron,S. Masuko,A. Raithatha,K. Bauchmuller,M. Wiles,N. Ahmad,Jack Barker,Y. Jackson,F. Kibutu,Sara W. Bird,G. Watson,Javier Martin,E. Bevan,C. W. Brown,D. Trodd,K. English,Graeme I. Bell,L. Wilcox,A. Katary,S. Gopal,V. Lake,N. Harris,S. Metherell,Elizabeth J. Radford,F. Moore,H. Bancroft,J. Daglish,M. Sangombe,M. Carmody,Johanna Rhodes,M. Bellamy,Atul Garg,A. Kuravi,E. Virgilio,P. Ranga,Javed Butler,L. Botfield,C. Dexter,Jason Fletcher,P. Shanmugasundaram,G. Hambrook,I. Burn,K. Manso,D. Thornton,J. Tebbutt,R. Penn,J. Hulme,Sabah N. A. Hussain,Z. Maqsood,Sarah B. Joseph,J. Colley,A. Hayes,C. Ahmed,R. Haq,S. Clamp,Rakesh Kumar,M. Purewal,B. Baines,M. Frise,N. Jacques,H. Coles,J. Caterson,S. G. Rai,M. Brunton,E. Tilney,L. Keating,Andrew Walden,David Antcliffe,Stephen J. Brett,Anthony C. Gordon,M. Templeton,Rocio Rojo,D. Banach,S. S. Arias,Z. Fernandez,P. Coghlan,D. Williams,Catherine Jardine,J. Bewley,Katie Sweet,L. Grimmer,Randall S. Johnson,Z. Garland,B. Gumbrill,C. Phillips,L. Ortiz-Ruiz de Gordoa,E. Peasgood,Ascanio Tridente,K. Shuker,S. Greer,C. Lynch,C. Pothecary,L. Roche,B. Deacon,K. Turner,Jai Rup Singh,G. S. Howe,P. Paul,Michael Gill,I. Wynter,V. Ratnam,S. Shelton,Jay Naisbitt,J. Melville,R. Baruah,Siouxzy Morrison,A. McGregor,V. Parris,M. Mpelembue,S. Srikaran,C. Dennis,A. Sukha,M. Verlander,K. Holding,K. Riches,C. Downes,C. Swan,A. Rostron,Ajit Roy,L. Woods,S. Cornell,F. Wakinshaw,Ben Creagh-Brown,H. Blackman,A. Salberg,E. N. Smith,S. Donlon,S. Mtuwa,N. Michalak-Glinska,S. Stone,C. Beazley,V. Pristopan,N. Nikitas,L. Lankester,Christine A. Wells,A. S. Raj,Katherine Fletcher,R. Khade,G. Tsinaslanidis,Michael MacMahon,Stephen J. Fowler,T. Coventry,Richard B. Stewart,L. Wren,E. Mwaura,L. Mew,D. Scaletta,Frances M K Williams,K. Inweregbu,N. Lancaster,Matthew Cunningham,A. Daniels,L. Harrison,S. Hope,S Jones,A. Crew,G. Wray,John N. S. Matthews,R. Crawley,J. Carter,I. Birkinshaw,J. Ingham,Z. Scott,H. Pearson,K. Howard,R. Joy,S. Roche,M. Clark,S. Purvis,Alanna C. Morrison,David P. Strachan,S. Clements,K. Black,Chetan Parmar,A. Altabaibeh,Kenneth J. Simpson,L. Mostoles,K. Gilbert,L. Ma,A. Alvaro,Mark G. Thomas,B. Faulkner,R. Worner,Kate Hayes,E. Gendall,H. Blakemore,B. Borislavova,E. Goff,Alan Vuylsteke,L. Mwaura,J. Zamikula,L Garner,A. Mitchell,S. Mepham,L. Cagova,A. Fofano,H. Holcombe,K. Praman,Tamas Szakmany,A. E. Heron,S. Cherian,S. Cutler,A. Roynon-Reed,G. Randell,K. Convery,K. Stammers,D. Fottrell-Gould,L. Hudig,J. Keshet-Price,Mark J. Peters,L. O'Neill,Swapan K. Ray,H. Belfield,T. McHugh,Graeme Jones,O. Akinkugbe,A. Tomas,E. Abaleke,E. Beech,H. Meghari,S. Yussuf,A. Bamford,B. Hairsine,E. Dooks,F. Farquhar,S. Packham,H. Bates,Lawrence Armstrong,C. Kaye,A. Allan,J. Medhora,J. Liew,A. Botello,F. Anderson,Rebecca Cusack,H. Golding,K. Prager,Thomas N. Williams,S. Leggett,K. Golder,M. Male,O. Jones,K. Criste,M. Marani,V. Anumakonda,V. Amin,K. Karthik,R. Kausar,E. Anastasescu,K. Reid,Mari Smith,Anil Hormis,Rosie M. Walker,T. Duncan,A. Uriel,Andrew Ustianowski,H. T-Michael,M. Bruce,K. Connolly,Kenneth Smith,Roland Partridge,Darren K. Griffin,M. Mupudzi,N. Muchenje,Dori-Ann Martin,H. Filipe,C. Eastgate,C. Jackson,Andrew Gratrix,L. Foster,Victoria Martinson,E. Stones,C. Abernathy,P. Parkinson,A. Reed,C. Prendergast,Peter Rogers,M. Woodruff,R. Shokkar,S Kaul,A. Barron,C. Collins,S. Beavis,A. Whileman,K. Dale,J. Hawes,K. Pritchard,R. Gascoyne,L. Stevenson,R. Jha,L. Lim,V. Krishnamurthy,Roy Parker,I. Turner-Bone,L. Wilding,A. Reddy,S. Whiteley,E. Wilby,C. Howcroft,A. Aspinwall,Sue Charlton,B. Ogg,Donna J. Menzies,Richard Pugh,E. Allan,R. Lean,F. Davies,J. Easton,X. Qiu,Shriya B. Kumar,K. Darlington,G. Houston,P. O'Brien,T. Geary,Jay Allan,A. Meikle,Grant L. Hughes,M. Balasubramaniam,S. Latham,E. McKenna,R. Flanagan,S. Sathe,Emma L. Davies,M. Chablani,A. Kirkby,K. Netherton,S. Archer,Bryan Yates,C. Ashbrook-Raby,Sarah Cole,M. Casey,L. Cabrelli,Stephen Chapman,A. Hutcheon,C. Whyte,C. Almaden-Boyle,Natalie Pattison,Claudina Cruz,A. Vochin,H. Kent,Adri A. M. Thomas,S. Murdoch,B. David,M. Penacerrada,G. Lubimbi,V. Bastion,R. Wulandari,Roberto Lorusso,J. Valentine,D. Clarke,A. Serrano-Ruiz,S. Hierons,C. Eckbad,L. Ramos,C. Demetriou,S. Mitchard,K. White,Nicholas J. White,Steven J. Pitts,D. Branney,J. Frankham,M. Watters,H. Langton,Rachel Prout,V. Page,T. Varghes,A. Cowton,A. Kay,K. Potts,M. Birt,Matthew Peter Kent,A. Wilkinson,E. B. Jude,V. Turner,H. Savill,J. McCormick,M. Coulding,S. Siddiqui,O. Mercer,H. Rehman,D. Potla,N. Capps,David S. Donaldson,H. Button,Terry Martin,K. Hard,A. Agasou,L. Tonks,T. Arden,Patricia A. Boyle,M. Carnahan,J. Strickley,Christopher M. Adams,D. Childs,R. Rikunenko,M. Leigh,M. Breekes,R. Wilcox,A. Bowes,H. Tiveran,F. Hurford,J. Summers,Austin Carter,Y. Hussain,L. Ting,A. Javaid,N. Motherwell,H. Moore,H. Millward,S. Jose,N. Schunki,A. Noakes,C. Clulow,G. Sadera,Reni Jacob,Chris Jones,M. Blunt,Z. Coton,H. Curgenven,S. M. Ally,K. Beaumont,M. Elsaadany,K. Fernandes,I. Ali Mohamed Ali,H. Rangarajan,V. Sarathy,S. Selvanayagam,D. Vedage,M. White,N. Truman,Srikanth Chukkambotla,S. Keith,J. Cockerill-Taylor,J. Ryan-Smith,R. Bolton,P. Springle,J. Dykes,Jo Thomas,Muzamil Majid Khan,M. T. Hijazi,E. Massey,G. Croston,Henrik Reschreiter,Julie Camsooksai,S. Patch,S. Jenkins,C. Humphrey,B. Wadams,M. Msiska,O. Adanini,B. Attwood,P. Parsons,Kate Tatham,S. Jhanji,E. Black,A. Dela Rosa,R. Howle,B. Thomas,T. Bemand,R. Raobaikady,R. Saha,Nikki Staines,A. Daniel,J. Finn,J. Hutter,P. Doble,C. Shovelton,C. Pawley,T. Kannan,Michael Hill,E. Combes,S. Monnery,T. Joefield,M. Popescu,M. Thankachen,M. Oblak,Jeff Little,S. McIvor,A. Brady,H. Whittle,H. Prady,R. Chan,A. Ahmed,Andrew D. Morris,C. Gibson,E. Gordon,S. Keenan,H. Quinn,S. Benyon,S. Marriott,L. Zitter,L. Park,K. Baines,M. Lyons,M. Holland,N. Keenan,M. Young,S. Garrioch,J. Dawson,M. Tolson,B. Scholefield,R. Bi,Neil Richardson,N. Schumacher,T. Cosier,G. Millen,A. Higham,S. Turki,L. Allen,N. Crisp,T. Hazleton,A. Knight,J. Deery,C. Price,S. Turney,S. Tilbey,E. Beranova,Derek W. Wright,L. George,S. Twiss,S. Wadd,K. Postlethwaite,P. Gondo,B. Masunda,A. Kayani,B. Hadebe,J. Whiteside,N. Clarke,Phil Donnison,F. Trim,I. Leadbitter,D. Butcher,S. O'Sullivan,B. Purewal,Scott C. Bell,V. Rivers,R. O'Leary,J. Birch,E. Collins,Stephen K. Anderson,K. Hammerton,E. Andrews,K. Burns,I. Edmond,A. Todd,J. Donnachie,P. Turner,L. Prentice,L. Symon,N. Runciman,F. Auld,M. Halkes,P. Mercer,L. Thornton,G. Debreceni,J. Wilkins,V. Crickmore,G. Subramanian,Robert Marshall,C. Jennings,M. Latif,L. Bunni,M. Spivey,S. Bean,K. Burt,Vanessa Linnett,J. Ritzema,A. Sanderson,W. McCormick,M. Bokhari,R. Kapoor,D. Loader,A. Ayers,W. Harrison,J. North,Z. Belagodu,R. Paramsothy,O. Olufuwa,A. Gherman,B. Fuller,C. Stuart,O. Kelsall,Carrie A. Davis,L. Wild,Henry Wood,Jessica Thrush,A. Durie,K. Austin,K. Archer,P. Anderson,C. Vigurs,C. Thorpe,E. Knights,N. Boyle,Alkes L. Price,A. Kubisz-Pudelko,D. Wood,Amy Lewis,S. Board,L. Pippard,John R. B. Perry,K. Beesley,A. Rattray,E. Lee,L. Lennon,K. Douglas,D. Bell,R. Boyle,L. Glass,M. Nauman Akhtar,K. Dent,D. Potoczna,S. Pearson,E. Horsley,S. Spencer,D. Mullan,D. Skinner,J. Gaylard,R. Barber,C. Hewitt,A. Hilldrith,S. Shepardson,M. Wills,K. Jackson-Lawrence,A. Gupta,E. Timlick,C. Gorman,Igor Otahal,A. Gales,S. Coetzee,Christian Sell,M. Raj,M. Peiu,S. Quaid,E. Watson,Katherine S. Elliott,J. Mallinson,B. Chandler,A. Turnbull,C. Finch,C. Holl,J.A. Cooper,Anthony Evans,W. Khaliq,Andrea M. Collins,E. T. Gude,N. Love,L. van Koutrik,John A. Hunt,D. Kaye,Eva Fisher,A. Brayne,V. Tuckey,P. Jackson,J. Parkin,A. Tariq,Henry Houlden,A. Tucci,John Hardy,E. Moncur,J. Highgate,A. Cowley,A. Mitra,R. Stead,T. Behan,C. Burnett,M. Newton,E. Heeney,R. Pollard,J. Hatton,Amita Patel,Vidya Kasipandian,S. Allibone,R. M. Genetu,L. O'Brien,Z. Omar,E. Perkins,Kevin A. Davies,D. Tetla,B. Shelley,V. Irvine,Samantha J. Williams,Patricia Williams,J. Goodsell,R. Tutton,L. Bough,B. Winter-Goodwin,R. Kitson,J. Pinnell,Anthony J. Wilson,T. Nortcliffe,T. Wood,M. Home,K. Holdroyd,Matthew R. Robinson,R. Shaw,J. Greig,M. Brady,A. Haigh,L. Matupe,M. Usher,S. Mellor,S. Dale,L. Gledhill,L. Shaw,G. Turner,Donna Kelly,B. Anwar,Heather L. Riley,H. Sturgeon,A. Ali,L. Thomis,D. Melia,A. Dance,SE Humphreys,I. Frost,V. Gopal,Jo Godden,A. Holden,S. Swann,Tony Smith,M. Clapham,U. Poultney,R. Harper,P. Rice,R. Reece-Anthony,B. Gurung,S. Moultrie,M. Odam,Andreas Mayer,A. Bellini,A. Pickard,J. Bryant,N. Roe,J. Sowter,K. Lang,Jenny C. Taylor,P. Barry,Maria Hobrok,H. Tench,R. Wolf-Roberts,H. McGuinness,R. Loosley,Daniel B Hawcutt,L. Rad,L. O'Malley,P. Saunderson,G. Seddon,Tim J. Anderson,N. Rogers,J. Ruddy,M. Harkins,C. Beith,A. McAlpine,L. Ferguson,Paul Grant,S. MacFadyen,M. McLaughlin,T. Baird,S. Rundell,B. Welsh,R. Hamill,F. Fisher,J. Gregory,Campbell A,S. Smuts,J Kenneth Baillie,J Kenneth Baillie,Gail Carson,Beatrice Alex,B. Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Graham S Cooke,Annemarie B Docherty,Jake Dunning,A. da Silva Filipe,Tom Fletcher,Christopher A Green,Ewen M Harrison,Julian A. Hiscox,Ho A. Y. W.,Peter Horby,Samreen Ijaz,S. Khoo,W. S. Lim,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Mahdad Noursadeghi,Massimo Palmarini,William A. Paxton,Georgios Pollakis,Nicholas Price,Andrew Rambaut,David Robertson,Vanessa Sancho-Shimizu,Janet T Scott,T I de Silva,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,David I. Stuart,R.S. Tedder,E. Thomson,Alfred A.R. Thompson,Ryan S Thwaites,L Turtle,Maria Zambon,Hayley Hardwick,Chloe Donohue,Ronan A Lyons,Lisa Norman,Riinu Pius,Thomas M Drake,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,C. A. Shaw,Jo Dalton,Michelle Girvan,Egle Saviciute,Stuart K. Roberts,Janet Harrison,Laura Marsh,Marie Connor,Sophie Halpin,Carrol Gamble,Gary Leeming,Murray Wham,William Greenhalf,V. Shaw,Sarah D. McDonald,Andrea Ganna,Patrick Sulem,D A van Heel,M. Cordioli,Gardar Sveinbjornsson,M. E. K. Niemi,Janie F. Shelton,A. J. Shastri,C. Ye,C. H. Weldon,T. Filshtein-Sonmez,D. Coker,A. Symons,J. Esparza-Gordillo,Stella Aslibekyan,Adam Auton,J. E. Krieger,E. Marques,C. E. Jannes,Francesca Mari,S. Daga,Margherita Baldassarri,Elisa Benetti,Simone Furini,Chiara Fallerini,Francesca Fava,Floriana Valentino,G. Doddato,Annarita Giliberti,Rossella Tita,Sara Amitrano,Mirella Bruttini,S. Croci,I. Meloni,A. M. Pinto,E. Frullanti,Maria Antonietta Mencarelli,C. L. Rizzo,Francesca Montagnani,L. Di Sarno,A. Tommasi,Marta Palmieri,Arianna Emiliozzi,M. Fabbiani,Barbara Rossetti,Giacomo Zanelli,Elena Bargagli,Laura Bergantini,Miriana d'Alessandro,Paolo Cameli,D. Bennet,Federico Anedda,Simona Marcantonio,Sabino Scolletta,Federico Franchi,Maria Antonietta Mazzei,S. Guerrini,Edoardo Conticini,Luca Cantarini,Bruno Frediani,D. Tacconi,C. Spertilli,M. Feri,Abele Donati,R. Scala,L. Guidelli,G. Spargi,M. Corridi,C. Nencioni,L. Croci,G. P. Caldarelli,M. Spagnesi,P. Piacentini,M. Bandini,E. Desanctis,S. Cappelli,A. Canaccini,A. Verzuri,V. Anemoli,A. Ognibene,M. Vaghi,A d'Arminio Monforte,Esther Merlini,M. U. Mondelli,S. Mantovani,S. Ludovisi,Massimo Girardis,S. Venturelli,M. Sita,Andrea Cossarizza,A. Antinori,Alessandra Vergori,Stefano Rusconi,M. Siano,A. Gabrieli,Agostino Riva,Daniela Francisci,Elisabetta Schiaroli,P. G. Scotton,F. Andretta,S. Panese,R. Scaggiante,F. Gatti,S. G. Parisi,Francesco Castelli,M. E. Quiros-Roldan,P. Magro,Isabella Zanella,M. Della Monica,Carmelo Piscopo,Mario Capasso,Roberta Russo,Immacolata Andolfo,Achille Iolascon,G. Fiorentino,M. Carella,Marco Castori,Giuseppe Merla,Filippo Aucella,P. Raggi,C. Marciano,R. Perna,Matteo Bassetti,A. Di Biagio,M. Sanguinetti,L. Masucci,Serafina Valente,Marco Mandalà,A. Giorli,L. Salerni,P. Zucchi,P. Parravicini,E. Menatti,S. Baratti,T. Trotta,F. Giannattasio,G. Coiro,F. Lena,D. A. Coviello,Cristina Mussini,G. Bosio,E. Martinelli,Sandro Mancarella,L. Tavecchia,L. Crotti,N. Picchiotti,M. Gori,C. Gabbi,M. Sanarico,S. Ceri,P. Pinoli,F. Raimondi,F. Biscarini,A. Stella,Xia Shen,Xia Shen,Chris P. Ponting,Angie Fawkes,Albert Tenesa,Albert Tenesa,Mark J. Caulfield,Richard H Scott,K Rowan,Lee Murphy,Peter J. M. Openshaw,Peter J. M. Openshaw,Malcolm G Semple,Veronique Vitart,James F. Wilson +1449 more
TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.
Journal ArticleDOI
Epistasis: too often neglected in complex trait studies?
Örjan Carlborg,Chris Haley +1 more
TL;DR: It is argued that epistasis should be accounted for in complex trait studies; current study designs for detecting epistasis are critically assessed and how these might be adapted for use in additional populations, including humans.
Journal ArticleDOI
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
Anne-Sophie Van Laere,Matthew Nguyen,Martin H. Braunschweig,Carine Nezer,Catherine Collette,Laurence Moreau,Alan Archibald,Chris Haley,Nadine Buys,Michael Tally,Göran Andersson,Michel Georges,Leif Andersson,Leif Andersson +13 more
TL;DR: This study establishes a causal relationship between a single-base-pair substitution in a non-coding region and a QTL effect, and supports the long-held view that regulatory mutations are important for controlling phenotypic variation.