G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Schwannomin: new insights into this member of the band 4.1 superfamily
TL;DR: What is known about the band 4.1 superfamily of proteins, which includes ezrin, moesin, radixin, and talin, as well as several protein tyrosine phosphatases, is examined.
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SKOR1 has a transcriptional regulatory role on genes involved in pathways related to restless legs syndrome.
Faezeh Sarayloo,Faezeh Sarayloo,Dan Spiegelman,Daniel Rochefort,Fulya Akçimen,Fulya Akçimen,Rachel De Barros Oliveira,Patrick A. Dion,Patrick A. Dion,Guy A. Rouleau,Guy A. Rouleau +10 more
TL;DR: Pathway and gene set enrichment analyses of the differentially expressed genes showed enrichment of genes involved in neurodevelopment and iron metabolism, two RLS relevant pathways that were previously found to be enriched in the latest RLS GWAS meta-analysis.
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A Set of STS Assays Targeting the Chromosome 22 Physical Framework Markers
Mia MacCollin,Donna M. Romano,Marcia L. Budarf,Christopher T. Denny,James A. Trofatter,Anil Menon,Guy A. Rouleau,Bertrand Fontaine,Beverly S. Emanuel,James F. Gusella +9 more
TL;DR: 21 STS assays for loci on human chromosome 22 are designed to make these loci available to the research community without physical transfer of materials and will serve as start points for further efforts to physically map chromosome 22 with yeast artificial chromosome clones.
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CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem.
Andrea Lessa Benedet,Lei Yu,Aurélie Labbe,Sulantha Mathotaarachchi,Tharick A. Pascoal,Monica Shin,Min-Su Kang,Serge Gauthier,Guy A. Rouleau,Judes Poirier,David A. Bennett,Pedro Rosa-Neto +11 more
TL;DR: Findings point to an association between CYP2C19 polymorphism and Aβ pathology, suggesting a protective effect of the MA of rs4388808, and the biological mechanism by which this genetic variation may act as a protective factor merits further investigation.
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Genetic linkage studies in familial frontal epilepsy: exclusion of the human chromosome regions homologous to the El-1 mouse locus.
Iscia Lopes-Cendes,Iscia Lopes-Cendes,H.A. Phillips,Ingrid E. Scheffer,John C. Mulley,Richard Desbiens,Eva Andermann,Fernando Cendes,Simon Verret,F. Andermann,Samuel F. Berkovic,Guy A. Rouleau +11 more
TL;DR: Polymorphic microsatellite markers covering these candidate regions were used for genotyping individuals in the three larger families ascertained, one of which is French-Canadian and two are Australian.