G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Analysis of oncogene expression in primary human gliomas: Evidence for increased expression of the ros oncogene
TL;DR: The results suggest that increased ros expression may play a role in tumorigenesis in a significant proportion of gliomas, suggesting a possible role for these oncogenes in individual tumors but no generalized role in development or progression of human glioma.
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Cognitive impairment in ARCA-1, a newly discovered pure cerebellar ataxia syndrome.
Robert Laforce,James P. Buteau,Jean-Pierre Bouchard,Guy A. Rouleau,Rémi W. Bouchard,Nicolas Dupré +5 more
TL;DR: It is confirmed that pure cerebellar damage as seen in ARCA-1 is associated with significant cognitive impairments but not with psychiatric comorbidity, and an indirect participation of the dorsolateral prefrontal and posterior parietal cortical areas to the cerebrocerebellar circuit is favoured.
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Data sharing as a national quality improvement program: reporting on BRCA1 and BRCA2 variant-interpretation comparisons through the Canadian Open Genetics Repository (COGR)
Matthew S. Lebo,Matthew S. Lebo,Kathleen-Rose Zakoor,Kathy Chun,Marsha Speevak,John S. Waye,Elizabeth McCready,J.S. Parboosingh,Ryan E. Lamont,Harriet Feilotter,Ian Bosdet,Tracy Tucker,Sean D. Young,Aly Karsan,George S. Charames,George S. Charames,George S. Charames,Ronald Agatep,Elizabeth Spriggs,Caitlin Chisholm,Nasim Vasli,Hussein Daoud,Olga Jarinova,Robert Tomaszewski,Stacey Hume,Sherryl Taylor,Mohammad R. Akbari,Jordan Lerner-Ellis,Ron Agatep,Peter Ainsworth,Melyssa Aronson,Raveen K. Basran,Andre Blavier,Andrea Blumenthal,Kym M. Boycott,Michael Brudno,Kathleen Buckley,Jodi Campbell,Philippe M. Campeau,Melanie Care,Nancy Carson,Ronald F. Carter,George Charames,George Charames,George Charames,David Chitayat,George Chong,Edmond Chouinard,Kenneth J. Craddock,Rod Docking,Andrea Eisen,Hanna Faghfoury,Sandra A. Farrell,Bridget A. Fernandez,Marc Fiume,Cynthia Forster-Gibson,Jan M. Friedman,William D. Foulkes,Peter Goodhand,Jessica Gu,Robert A. Hegele,Spring Holter,Sheri Horsburgh,Lauren Hughes,Franny Jewett,Anne K. Junker,Sam Khalouei,Joan H.M. Knoll,Elena Kolomeitz,Bartha Maria Knoppers,Ryan E. Lamont,Matthew Lebo,Matthew Lebo,Georges Maire,Christian R. Marshall,Grant A. Mitchell,Michael J Moorhouse,Chantal F. Morel,Tanya N. Nelson,Abdul Noor,Brian O'Connor,Darren D. O’Rielly,Francis Ouellette,Jillian S. Parboosingh,Hilary Racher,Peter N. Ray,Heidi L. Rehm,Christie Riddell,Jean-Baptiste Rivière,David S. Rosenblatt,Guy A. Rouleau,Andrea Ruchon,Peter J. B. Sabatini,Bekim Sadikovic,Kara Semotiuk,Stephen W. Scherer,Cheryl Shuman,Josh Silver,Katherine A. Siminovitch,Lesley Solomon-Izsak,Jean-François Soucy,Marsha Speevak,James Stavropoulos,Lincoln Stein,Rhonda Tannenbaum,Deborah Terespolsky,Richard F. Wintle,Beatrix Wong,Nora Wong,Marina Wang,Nicholas A. Watkins,Shana White,Michael O. Woods,Philip Wyatt +113 more
TL;DR: A Canadian interinstitutional quality improvement program for DNA-variant interpretations will allow clinicians and patients to make more informed decisions and lead to better patient outcomes by Sharing of variant knowledge by clinical diagnostic laboratories.
Journal ArticleDOI
Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes
Osman El-Maarri,Muhieddine Seoud,Jean-Baptiste Rivière,Johannes Oldenburg,Jörn Walter,Guy A. Rouleau,Rima Slim +6 more
TL;DR: The data suggest that the abnormal methylation in familial biparental molar tissues was acquired de novo in the patients'germline as a result of a false reprogramming or during the postzygotic development of the conceptuses that led to moles.
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No association between the PREP gene and lithium responsive bipolar disorder.
TL;DR: The findings do not support the hypothesis that genetic variation in this gene plays a major role in the etiology of BD or Li response, and PREP is an interesting candidate gene to investigate in genetic studies of BD.