G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
Papers
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Posted ContentDOI
Convergent transcriptomic targets of propranolol and primidone identify potential biomarkers for essential tremor
Charles-Etienne Castonguay,Charles-Etienne Castonguay,Charles-Etienne Castonguay,Calwing Liao,Calwing Liao,Anouar Khayachi,Gabrielle Houle,Gabrielle Houle,Jay P. Ross,Jay P. Ross,Patrick A. Dion,Guy A. Rouleau +11 more
TL;DR: In this article, RNA-sequencing was used to identify differentially expressed genes in both cortical and cerebellar DAOY and neural progenitor cells for 5 days with clinical concentrations of propranolol and primidone.
Journal ArticleDOI
Progress in the genetics of restless legs syndrome: the path ahead in the era of whole-genome sequencing
TL;DR: Several small-scale hypothesis-based candidate gene studies were performed for RLS, none of which have been replicated in additional populations, and no definitive causal variant or gene has been identified based on this work.
Posted ContentDOI
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation
Franziska Paul,Calista Keow Leng Ng,Shahriar Nafissi,Yalda Nilipoor,Ali Reza Tavasoli,Carine Bonnard,Carine Bonnard,Pui-Mun Wong,Nasrinsadat Nabavizadeh,Nasrinsadat Nabavizadeh,Nasrinsadat Nabavizadeh,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Charles B. L. M. Majoie,Hane Lee,Stanley F. Nelson,Ziv Gan-Or,Ziv Gan-Or,Guy A. Rouleau,Guy A. Rouleau,Paul P. Van Veldhoven,Rami Massie,Rami Massie,Raoul C.M. Hennekam,Ariana Kariminejad,Bruno Reversade +25 more
TL;DR: In this paper, the authors identified recessively-acting germline alleles p.Arg180Gly and p.Gly183Arg which are both situated in the FYVE domain of RBSN and found that these variants abrogate binding to its cognate substrate PI3P and thus prevent its translocation to early endosomes.
letters-and-commentsDOI
Brain health for all on World Brain Day 2022
Tissa Wijeratne,Claudio L. Bassetti,Wolfgang Grisold,David W. Dodick,Guy A. Rouleau,Steven Lewis,Richard J Stark,Morris Freedman,Alla Guekht,Riadh Gouider,Marco T Medina,Chandrashekhar Meshram,Hamidon Basri,Augustina Charway-Felli,Maged Abdel Naseer +14 more
Book ChapterDOI
Genetics of Chiari Malformation and Syringomyelia
TL;DR: The current knowledge of genetic determinants is discussed, including a review of familial aggregation and clustering, twin studies and associations with known genetic syndromes, and canine models for Chiari and syringomyelia are detailed.