G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Whole genome sequencing and variant discovery in the ASPIRE autism spectrum disorder cohort
Daniel B. Callaghan,Sanja Rogic,Powell Patrick Cheng Tan,Kristina Calli,Ying Qiao,Robert Baldwin,Matthew Jacobson,Manuel Belmadani,Nathan Holmes,Chang Yu,Yanchen Li,Yingrui Li,Franz‐Edward Kurtzke,Boris Kuzeljevic,An Yi Yu,Melissa Hudson,Amy J.M. Mcaughton,Yuchen Xu,Alexandre Dionne-Laporte,Alexandre Dionne-Laporte,Simon Girard,Ping Liang,Evica Rajcan Separovic,Xudong Liu,Guy A. Rouleau,Guy A. Rouleau,Paul Pavlidis,M. E. Suzanne Lewis +27 more
TL;DR: Five novel de novo damaging variants as well as several likely damaging variants of unknown inheritance are reported; these include two novel deNovo variants in the well‐established ASD gene SCN2A.
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The dynamism of PABPN1 nuclear inclusions during the cell cycle.
A. Marie-Josée Sasseville,Antoine W. Caron,Lucie Bourget,Arnaud F. Klein,Marie-Josée Dicaire,Guy A. Rouleau,Bernard Massie,Bernard Massie,Yves Langelier,Bernard Brais +9 more
TL;DR: The observations demonstrated that the GFP-b13AlaPABPN1 INIs are dynamic structures that can disassemble during mitosis, however, their presence in cells occasionally led to apoptosis, which could contribute in vivo to the late onset of this disease.
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A 405-kb cosmid contig and HindIII restriction map of the progressive myoclonus epilepsy type 1 (EPM1) candidate region in 21q22.3.
TL;DR: A cosmid contig of the candidate EPM1 region in 21q22.3 is assembled, containing the genetic material required for the isolation of expressed sequences and the identification of the gene defective in E PM1 and possibly other disorders mapping to this region.
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Anticipation in familial cavernous angioma: ascertainment bias or genetic cause
Adrian M. Siegel,Adrian M. Siegel,Adrian M. Siegel,F. Andermann,AmanPreet Badhwar,AmanPreet Badhwar,Guy A. Rouleau,M. Dam,H. C. Hopf,Johannes Dichgans,Matthias Sturzenegger,N. J. Hopf,N. Yasui,F. Stepper,Monika Killer,J. A. L. Vanneste,N. Acciarri,P. Drigo,Jakob Christensen,V. Braun,D. Könü,Eva Andermann +21 more
TL;DR: The human brain is a “spatially aggregating organ” and the role of language and language impairment in the development of Alzheimer’s disease is “an important role”, according to Munksgaard.
Journal ArticleDOI
Comparative Analysis of the Expression Profile of Wnk1 and Wnk1/Hsn2 Splice Variants in Developing and Adult Mouse Tissues
Masoud Shekarabi,Ron G. Lafreniere,Rébecca Gaudet,Janet Laganière,Martin M Marcinkiewicz,Patrick A. Dion,Guy A. Rouleau +6 more
TL;DR: It is suggested that the expression of the Wnk1 splice variant containing the Hsn2 exon is prominent during developing and in adult mouse tissues, suggesting its important role in the development and maintenance of the nervous system.