G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal Article
Molecular Genetic Analysis of Chromosome 22 in 81 Cases of Meningioma
TL;DR: The data from case 11 of the series suggests that the meningioma and the neurofibromatosis-2 loci are separate entities, which may suggest that tumors of males have preferentially smaller rearrangements on chromosome 22q than those of females or that the male and female cases with no detected aberrations have another mechanism of oncogenesis.
Journal ArticleDOI
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
Juliane Winkelmann,Darina Czamara,Barbara Schormair,Franziska Knauf,Eva C. Schulte,Claudia Trenkwalder,Yves Dauvilliers,Olli Polo,Birgit Högl,Klaus Berger,Andrea Fuhs,Nadine Gross,Karin Stiasny-Kolster,Wolfgang H. Oertel,Cornelius G. Bachmann,Walter Paulus,Lan Xiong,Jacques Montplaisir,Guy A. Rouleau,Ingo Fietze,Jana Vavrova,David Kemlink,Karel Sonka,Sona Nevsimalova,Siong Chi Lin,Zbigniew K. Wszolek,Carles Vilariño-Güell,Matthew J. Farrer,Viola Gschliesser,Birgit Frauscher,Tina Falkenstetter,Werner Poewe,Richard P. Allen,Christopher J. Earley,William G. Ondo,Wei Dong Le,Derek Spieler,Maria Kaffe,Alexander Zimprich,Johannes Kettunen,Johannes Kettunen,Markus Perola,Markus Perola,Kaisa Silander,Kaisa Silander,Isabelle Cournu-Rebeix,Isabelle Cournu-Rebeix,Marcella Francavilla,Marcella Francavilla,Claire Fontenille,Claire Fontenille,Bertrand Fontaine,Bertrand Fontaine,Pavel Vodicka,Holger Prokisch,Peter Lichtner,Paul E. Peppard,Juliette Faraco,Emmanuel Mignot,Christian Gieger,Thomas Illig,H.-Erich Wichmann,Bertram Müller-Myhsok,Thomas Meitinger +63 more
TL;DR: Six RLS susceptibility loci of genome-wide significance are identified, two of them novel: an intergenic region on chromosome 2p14 (rs6747972), and a locus on 16q12.1 (rs3104767), a linkage disequilibrium block of 140 kb containing the 5′-end of TOX3 and the adjacent non-coding RNA BC034767.
Journal ArticleDOI
Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton
Markku Sainio,Fang Zhao,Leena Heiska,Ossi Turunen,M. den Bakker,Ellen C. Zwarthoff,Mohini Lutchman,Guy A. Rouleau,Juha E. Jääskeläinen,Antti Vaheri,Olli Carpén +10 more
TL;DR: NF2 protein possesses functional properties of an ERM family member, and interaction between NF2 protein and the actin-containing cytoskeleton was indicated by partial colocalization, by cytochalasin B-induced coclustering, and by retention of NF2protein in the detergent-insoluble fraction.
Journal ArticleDOI
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
Barbara Schormair,Chen Zhao,Steven Bell,Erik Tilch,Aaro V. Salminen,Benno Pütz,Yves Dauvilliers,Ambra Stefani,Birgit Högl,Werner Poewe,David Kemlink,Karel Sonka,Cornelius G. Bachmann,Walter Paulus,Claudia Trenkwalder,Wolfgang H. Oertel,Magdolna Hornyak,Maris Teder-Laving,Andres Metspalu,Georgios M. Hadjigeorgiou,Olli Polo,Ingo Fietze,Owen A. Ross,Zbigniew K. Wszolek,Adam S. Butterworth,Nicole Soranzo,Willem H. Ouwehand,David J. Roberts,John Danesh,Richard P. Allen,Christopher J. Earley,William G. Ondo,Lan Xiong,Jacques Montplaisir,Ziv Gan-Or,Markus Perola,Pavel Vodicka,Christian Dina,Andre Franke,Lukas Tittmann,Alexandre F.R. Stewart,Svati H. Shah,Christian Gieger,Annette Peters,Guy A. Rouleau,Klaus Berger,Konrad Oexle,Emanuele Di Angelantonio,David A. Hinds,Bertram Müller-Myhsok,Juliane Winkelmann +50 more
TL;DR: A meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets and identified and replicated 13 new risk loci for restless legs syndrome and confirmed the previously identified sixrisk loci.
Journal ArticleDOI
Exome Sequencing Identifies FUS Mutations as a Cause of Essential Tremor
Nancy D. Merner,Simon Girard,Hélène Catoire,Cynthia V. Bourassa,Veronique V. Belzil,Jean-Baptiste Rivière,Pascale Hince,Annie Levert,Alexandre Dionne-Laporte,Dan Spiegelman,Anne Noreau,Sabrina Diab,Anna Szuto,Helene Fournier,John Verner Raelson,Majid Belouchi,Michel Panisset,Patrick Cossette,Nicolas Dupré,Geneviève Bernard,Sylvain Chouinard,Patrick A. Dion,Guy A. Rouleau +22 more
TL;DR: Exome sequencing is used to implement a simple approach to control for misdiagnosis of ET, as well as phenocopies involving sporadic and senile ET cases, and it is shown that the ET FUS nonsense mutation is degraded by the nonsense-mediated-decay pathway, whereas amyotrophic lateral sclerosis FUS mutant transcripts are not.