G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Investigation of C9orf72 repeat expansions in Parkinson's disease.
Hussein Daoud,Anne Noreau,Daniel Rochefort,Gabriel Paquin-Lanthier,Maude Turcotte Gauthier,Pierre Provencher,Emmanuelle Pourcher,Nicolas Dupré,Sylvain Chouinard,Nicolas Jodoin,Valérie Soland,Edward A. Fon,Patrick A. Dion,Guy A. Rouleau +13 more
TL;DR: No pathologic expansion was found in a cohort of patients suggesting that C9orf72 repeat expansions do not play a major role in the pathogenesis of Parkinson's disease.
Journal ArticleDOI
No association between the DRD3 Ser9Gly polymorphism and schizophrenia.
Ferid Fathalli,Guy A. Rouleau,Lan Xiong,Karim Tabbane,Chawki Benkelfat,Rosherrie DeGuzman,Danics Zoltan,Samarthji Lal,Sarogini D’cruz,Ridha Joober +9 more
TL;DR: The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported and neither allele A or G were preferentially transmitted from parents to affected offspring.
Journal ArticleDOI
Sensory and motor neuronopathy in a patient with the A382P TDP-43 mutation
Jean Philippe Camdessanché,Veronique V. Belzil,Guillemette Jousserand,Guy A. Rouleau,Christelle Créac’h,Philippe Convers,Jean Christophe Antoine +6 more
TL;DR: This case expands the phenotypic spectrum associated with mutations in the TARDBP gene and shows that sensory neurons can be severely damaged early in the course of the disease, following a propagating process, with an orderly progression from a focal starting point.
Journal ArticleDOI
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
Paul J. Hop,Ramona A. J. Zwamborn,Eilis Hannon,Gemma Shireby,Marta F. Nabais,Emma Walker,Wouter van Rheenen,Joke J.F.A. van Vugt,Annelot M. Dekker,Henk-Jan Westeneng,Gijs H.P. Tazelaar,Kristel R. van Eijk,Matthieu Moisse,Denis Baird,Ahmad Al Khleifat,Alfredo Iacoangeli,Nicola Ticozzi,Antonia Ratti,Jonathan Cooper-Knock,Karen E. Morrison,Pamela J. Shaw,A. Nazli Basak,Andrea Calvo,Cristina Moglia,Antonio Canosa,Maura Brunetti,Maurizio Grassano,Marc Gotkine,Yossef Lerner,Michal Zabari,Patrick Vourc'h,Philippe Corcia,Philippe Couratier,Jesus S. Mora Pardina,Teresa Salas,Patrick A. Dion,Jay P. Ross,Robert D. Henderson,Susan Mathers,Pamela A. McCombe,Merrilee Needham,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Karen A. Mather,Perminder S. Sachdev,Sarah Furlong,Fleur C. Garton,Anjali K. Henders,Tian Lin,Shyuan T. Ngo,Frederik J. Steyn,Leanne Wallace,Kelly L. Williams,Miguel Mitne Neto,Ruben J. Cauchi,Ian A. Blair,Matthew C. Kiernan,Vivian E. Drory,Mònica Povedano,Mamede de Carvalho,Susana Pinto,Markus Weber,Guy A. Rouleau,Vincenzo Silani,John Landers,Christopher Shaw,Peter Andersen,Allan F. McRae,Michael A. van Es,R. Jeroen Pasterkamp,Naomi R. Wray,Russell L. McLaughlin,Orla Hardiman,Kevin P. Kenna,Ellen A. Tsai,Heiko Runz,Leonard H. van den Berg,Philip Van Damme,Jonathan Mill,Bastiaan T. Heijmans,Peter A C 't Hoen,J. Van Meurs,Rick Jansen,Lude Franke,Dorret I. Boomsma,René Pool,Jenny van Dongen,Joukje J Hottenga,Marleen M.J. van Greevenbroek,Coen D.A. Stehouwer,Carla J.H. van der Kallen,Casper G. Schalkwijk,Cisca Wijmenga,Sasha Zhernakova,Ettje F. Tigchelaar,P. Eline Slagboom,Marian Beekman,Joris Deelen,Diana van Heemst,Jan H. Veldink,Cornelia M. van Duijn,Bert Hofman,Aaron Isaacs,André G. Uitterlinden,P. Mila Jhamai,Michael M. P. J. Verbiest,H. Eka D. Suchiman,Marijn Verkerk,Ruud van der Breggen,Jeroen van Rooij,Nico Lakenberg,Hailiang Mei,Maarten van Iterson,Michiel van Galen,Jan Bot,D. V. Zhernakova,Peter Van ‘t Hof,P.M. Van Deelen,Irene M.A. Nooren,Matthijs Moed,Martijn Vermaat,René Luijk,Marc Jan Bonder,Freerk van Dijk,Wibowo Arindrarto,Szymon M. Kielbasa,Morris A. Swertz,Erik W. van Zwet,Ammar Al-Chalabi,Gilbert Bensimon,Adriano Chiò,George Davey Smith +132 more
TL;DR: Analysis of DNA methylation patterns implicates metabolism, inflammation, and cholesterol pathways in ALS disease and survival, which will help the identification of disease-relevant mechanisms that could be targeted to block or delay ALS progression.
Journal ArticleDOI
LINGO1 variants in the French-Canadian population.
Cynthia V. Bourassa,Jean-Baptiste Rivière,Patrick A. Dion,Geneviève Bernard,Sabrina Diab,Michel Panisset,Sylvain Chouinard,Nicolas Dupré,Helene Fournier,John Verner Raelson,Majid Belouchi,Guy A. Rouleau +11 more
TL;DR: It is concluded that no association exists between the key variant rs9652490 and ET and the aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls.