G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Lithium-responsive affective disorders: no association with the tyrosine hydroxylase gene
P. Cavazzoni,Martin Alda,Gustavo Turecki,Guy A. Rouleau,Eva Grof,Rory Martin,Anne Duffy,Paul Grof +7 more
TL;DR: 54 patients who had shown definite long-term response to lithium monotherapy in spite of a high risk of recurrence as indicated by the previous clinical course were investigated, providing further evidence against a major role for the tyrosine hydroxylase gene in the etiology of major affective disorders.
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SPG7 mutations explain a significant proportion of French Canadian spastic ataxia cases
Karine Choquet,Martine Tétreault,Martine Tétreault,Sharon Yang,Roberta La Piana,Marie Josée Dicaire,Megan R. Vanstone,Jean Mathieu,Jean-Pierre Bouchard,Marie-France Rioux,Guy A. Rouleau,Kym M. Boycott,Jacek Majewski,Jacek Majewski,Bernard Brais +14 more
TL;DR: It is suggested that variants affecting the function of SPG7 are the fourth most common form of recessive ataxia in FC patients and that this gene should be considered in unresolved patients.
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Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes.
Calwing Liao,Alexandre D. Laporte,Dan Spiegelman,Fulya Akçimen,Fulya Akçimen,Ridha Joober,Patrick A. Dion,Patrick A. Dion,Guy A. Rouleau,Guy A. Rouleau +9 more
TL;DR: An ADHD transcriptome-wide association study is conducted and it is demonstrated that two of the previous GWAS hits can be largely explained by expression regulation, highlighting the power of TWAS to identify and prioritize putatively causal genes.
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Dopa-responsive dystonia due to a large deletion in the GTP cyclohydrolase I gene.
Yoshiaki Furukawa,Mark Guttman,Steven Sparagana,Steven Sparagana,Joel M. Trugman,Keith Hyland,Keith Hyland,Philip Wyatt,Anthony E. Lang,Guy A. Rouleau,Mitsunobu Shimadzu,Stephen J. Kish +11 more
TL;DR: It is concluded that a large genomic deletion in GCH1 may account for some “mutation‐negative” patients with dominantly inherited DRD.
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A new autosomal recessive spastic ataxia associated with frequent white matter changes maps to 2q33-34.
Isabelle Thiffault,Marie-France Rioux,Martine Tétreault,Jonathan Jarry,L. Loiselle,Josée Poirier,F. Gros-Louis,Jean Mathieu,Michel Vanasse,Guy A. Rouleau,J.P. Bouchard,J. Lesage,Bernard Brais +12 more
TL;DR: A group of 23 French-Canadian cases belonging to 17 families affected by an autosomal recessive spastic ataxia associated with frequent white matter changes is identified, pointing to a common pathway for pyramidal and cerebellar degeneration as both are often observed in recessive ataxias and complicated paraplegias.