G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
Papers
More filters
Journal ArticleDOI
Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues
Matthieu Y. Pasco,Dante Rotili,Lucia Altucci,Francesca Farina,Guy A. Rouleau,Antonello Mai,Christian Neri +6 more
TL;DR: The SIRT1/2 inhibitors 1-12, bearing different degrees of inhibition, were tested for protection against mutant PABPN1 toxicity in Caenorhabditis elegans, revealing a potential therapeutic application for muscle cell protection in OPMD.
Journal ArticleDOI
Migraine: Role of the TRESK two-pore potassium channel.
TL;DR: A review will elaborate on the possible role of the TRESK channel in regulating neuronal excitability, its role in migraine pathogenesis, and on promising therapeutic opportunities targeting this channel.
Journal ArticleDOI
UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis.
Hussein Daoud,Hamid Suhail,Anna Szuto,William Camu,François Salachas,Vincent Meininger,Jean-Pierre Bouchard,Nicolas Dupré,Patrick A. Dion,Guy A. Rouleau +9 more
TL;DR: In this article, the UBQLN2 gene was sequenced in 590 ALS patients of French and French-Canadian ancestry and two novel missense mutations (p.S155N and p.P189T) were identified in two individuals with sporadic ALS.
Journal ArticleDOI
Analysis of 14 CAG repeat-containing genes in schizophrenia
Ridha Joober,Chawki Benkelfat,André Toulouse,Ronald G. Lafrenière,Samarthji Lal,Senda Ajroud,Gustavo Turecki,David E. Bloom,Alain Labelle,Pierre Lalonde,Martin Alda,Kenneth Morgan,Roberta M. Palmour,Guy A. Rouleau +13 more
TL;DR: Preliminary results suggest that the hGT1 gene, or a gene in its vicinity, may be involved in the etiology of schizophrenia or in modifying the disease phenotype with regard to outcome and/or neuroleptic responsiveness.
Journal ArticleDOI
De novo truncating mutation in Kinesin 17 associated with schizophrenia.
Julien Tarabeux,Julien Tarabeux,Julien Tarabeux,Nathalie Champagne,Edna Brustein,Fadi F. Hamdan,Julie Gauthier,Mathieu Lapointe,Claudia Maios,Amélie Piton,Dan Spiegelman,Edouard Henrion,Bruno Millet,Bruno Millet,Judith L. Rapoport,Lynn E. DeLisi,Ridha Joober,Ferid Fathalli,Eric Fombonne,Laurent Mottron,Nadine Forget-Dubois,Michel Boivin,Jacques L. Michaud,Ronald G. Lafrenière,Pierre Drapeau,Marie-Odile Krebs,Marie-Odile Krebs,Guy A. Rouleau +27 more
TL;DR: The findings suggest that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder.