G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
Papers
More filters
Journal ArticleDOI
Polyglutamine-containing proteins in schizophrenia.
Ridha Joober,Chawki Benkelfat,Jannatipour M,Gustavo Turecki,Samarthji Lal,Jean-Louis Mandel,David E. Bloom,Pierre Lalonde,Iscia Lopes-Cendes,D. Fortin,Guy A. Rouleau +10 more
TL;DR: In this paper, the presence of polyglutamine-expanded tracts, encoded by CAG repeats, in total protein extracts derived from lymphoblastoid cell lines of schizophrenic patients was found.
Journal ArticleDOI
Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery.
Vincent Soubannier,Gilles Maussion,Mathilde Chaineau,Veronika Sigutova,Guy A. Rouleau,Thomas M. Durcan,Stefano Stifani +6 more
TL;DR: Robust and reliable derivation of astrocytes from human induced pluripotent stem cells (iPSCs) are described, providing evidence suggesting that human iPSC-derivedAstrocyte function and reactivation in healthy and pathological conditions of the human nervous system are suggested.
Journal ArticleDOI
Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia.
Veronique V. Belzil,Hussein Daoud,William Camu,Michael J. Strong,Patrick A. Dion,Guy A. Rouleau +5 more
TL;DR: Coding and noncoding variants located in the 3′-UTR region of the SIGMAR1 gene are not the cause of FTLD–MND in a targeted cohort of 25 individual familial ALS cases of Caucasian origin, and more than half of this targeted cohort is genetically explained by C9ORF72 repeat expansions.
Journal ArticleDOI
Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion
Rossella Spataro,Maria Kousi,Maria Kousi,Maria Kousi,Sali M.K. Farhan,Sali M.K. Farhan,Jason R. Willer,Jay P. Ross,Patrick A. Dion,Guy A. Rouleau,Mark J. Daly,Mark J. Daly,Mark J. Daly,Benjamin M. Neale,Benjamin M. Neale,Vincenzo La Bella,Nicholas Katsanis +16 more
TL;DR: The phenotypic spectrum associated with genetic variants in ATP13A2 that previously comprised Kufor-Rakeb syndrome, spastic paraplegia 78, and neuronal ceroid lipofuscinosis type 12 (CLN12), to also include juvenile-onset ALS, as supported by both genetic and functional data.
Journal ArticleDOI
De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects.
Andrea Accogli,Sara Calabretta,Judith St-Onge,Nassima Boudrahem-Addour,Alexandre Dionne-Laporte,Pascal Joset,Silvia Azzarello-Burri,Anita Rauch,Joel B. Krier,Elizabeth L. Fieg,Juan C Pallais,Allyn McConkie-Rosell,Marie T. McDonald,Sharon F. Freedman,Jean-Baptiste Rivière,Joël Lafond-Lapalme,Brittany N. Simpson,Robert J. Hopkin,Aurélien Trimouille,Julien Van-Gils,Amber Begtrup,Kirsty McWalter,Heron Delphine,Boris Keren,David Geneviève,Emanuela Argilli,Elliott H. Sherr,Mariasavina Severino,Guy A. Rouleau,Patricia T. Yam,Frédéric Charron,Myriam Srour +31 more
TL;DR: It is shown that cells expressing variants in the EC4-EC5 domains have a defect in cell-cell adhesion; this defect includes impaired binding in trans with N-cadherin-WT expressed on apposing cells.