G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder.
Michael Tseng,Martin Alda,Li Xu,Xiujun Sun,Jun-Feng Wang,Paul Grof,Gustavo Turecki,Guy A. Rouleau,L. Trevor Young +8 more
TL;DR: Low BDNF levels in lithium-responsive patients with bipolar disorder may constitute part of the pathophysiologic process of BD in a lithium- responsive subgroup of individuals with this disease, and a compensatory mechanism protecting the genetically predisposed unaffected relatives from phenotypic expression of BD is suggested.
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A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review.
Nancy D. Merner,Nancy D. Merner,Baudouin Forgeot d’Arc,Scott C. Bell,Gilles Maussion,Huashan Peng,Julie Gauthier,Liam Crapper,Fadi F. Hamdan,Jacques L. Michaud,Laurent Mottron,Guy A. Rouleau,Guy A. Rouleau,Carl Ernst +13 more
TL;DR: This case report supports the association of CHD8 mutations with classical autism, macrocephaly, infantile hypotonia, speech delay, lack of major ID, and psychopathology in late adolescence caused by insufficient dosage ofCHD8.
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Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation
Tracy Tucker,Alexandre Montpetit,David Chai,Susanna Chan,Sébastien Chénier,Bradley P. Coe,Allen Delaney,Patrice Eydoux,Wan L. Lam,Sylvie Langlois,Emmanuelle Lemyre,Marco A. Marra,Hong Qian,Guy A. Rouleau,David Vincent,Jacques L. Michaud,Jan M. Friedman,Jan M. Friedman +17 more
TL;DR: The findings demonstrate that different results are obtained with different platforms and illustrate the trade-off that exists between sensitivity and specificity, and supports the need for validating clinically important findings with a different technology.
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Soluble expanded PABPN1 promotes cell death in oculopharyngeal muscular dystrophy
Christiane Messaed,Patrick A. Dion,Aida Abu-Baker,Daniel Rochefort,Janet Laganière,Bernard Brais,Guy A. Rouleau +6 more
TL;DR: This is the first report directly indicating that nuclear aggregation in OPMD may reflect an active process by which cells sequester and inactivate the soluble toxic form of expPABPN1.
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Schizophrenia genetics: putting all the pieces together.
TL;DR: The aim of this review is to discuss the most important genetic studies made in the field to give a general perspective of where to go in the future.