G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
Papers
More filters
Journal ArticleDOI
Increased prevalence of schizophrenia spectrum disorders in relatives of neuroleptic-nonresponsive schizophrenic patients.
Ridha Joober,Guy A. Rouleau,Samarthji Lal,David E. Bloom,Pierre Lalonde,Alain Labelle,Chawki Benkelfat +6 more
TL;DR: Schizophrenic patients who do not respond to typical neuroleptics may suffer from a more familial form of schizophrenia compared to patients who are responders.
Journal ArticleDOI
Different gene loci for hyperkalemic and hypokalemic periodic paralysis.
Bertrand Fontaine,James A. Trofatter,Guy A. Rouleau,Tejvir S. Khurana,Jonathan L. Haines,Robert H. Brown,James F. Gusella +6 more
TL;DR: This paper excludes genetic linkage between hypokalemic periodic paralysis (HOKPP) and this sodium channel gene, demonstrating that there is non-allelic genetic heterogeneity among different forms of periodic paralysis.
Journal ArticleDOI
The proportion of mutations predicted to have a deleterious effect differs between gain and loss of function genes in neurodegenerative disease
TL;DR: In this article, three prediction programs, PolyPhen, Panther and SIFT, were queried for the reported missense mutations, and the most accurate distinction between gain and loss of function genes could be obtained when considering the mutations for which all three programs predicted the same result.
Journal ArticleDOI
Acute adverse reactions associated with angiotensin-converting enzyme inhibitors: genetic factors and therapeutic implications.
TL;DR: Preliminary studies have shown that patients with a history of developing side effects have a lower activity of an enzyme called aminopeptidase-P, which has an important role in degrading bradykinin.
Journal ArticleDOI
Autosomal dominant primary lateral sclerosis.
TL;DR: A French Canadian family with progressive involvement of the upper motor neuron that closely mimics the features of PLS is described, including 8 affected members in two generations of the family.