G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Mortality and causes of death in the Familial Intracranial Aneurysm study.
Laura Sauerbeck,Richard Hornung,Daniel Woo,Charles J Moomaw,Craig S. Anderson,E. Sander Connolly,Guy A. Rouleau,Robert D. Brown,Joseph P. Broderick +8 more
TL;DR: The overall mortality was similar for the affected and unaffected subjects in this cohort, but among the affected only, those with ruptured intracranial aneurysm had a higher mortality rate than those without ruptured.
Journal ArticleDOI
Cloning of the (11;22) translocation breakpoints of Ewing's sarcoma & peripheral neuroepithelioma
O. Delattre,Jessica Zucman,Béatrice Plougastel,Chantal Desmaze,Thomas Melot,Martine Peter,Pieter DeJong,Guy A. Rouleau,A. Aurias,Gilles Thomas +9 more
Journal ArticleDOI
Genetic Alterations in the Chromosome 22q12 Region Associated with Development of Neuroectodermal Tumors
Gilles Thomas,Olivier Delattre,Jessica Zucman,P. Merel,Chantal Desmaze,Thomas Melot,M. Sanson,Khê Hoang-Xuan,Béatrice Plougastel,Pieter DeJong,Guy A. Rouleau,Alain Aurias +11 more
Posted ContentDOI
Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids
Yoshitaka Tamaki,Jay P. Ross,Paria Alipour,Hélène Catoire,Daniel Rochefort,Makoto Urushitani,Ryosuke Takahashi,Joshua A. Sonnen,Stefano Stifani,Patrick A. Dion,Guy A. Rouleau +10 more
TL;DR: Assays with human cerebral organoids that replicate ALS pathophysiology have a promising strategy for creating readouts that could be used in future drug discovery efforts against ALS, and provide evidence that patient-derived pathogenic TDP-43 can mimic the prion-like propagation of T DP-43 pathology in human CNS tissue.
Journal ArticleDOI
Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.
Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Konstantin Senkevich,Konstantin Senkevich,Eric Yu,Eric Yu,Parizad Varghaei,Parizad Varghaei,Lynne Krohn,Lynne Krohn,Sara Bandres-Ciga,Alastair J. Noyce,Alastair J. Noyce,Guy A. Rouleau,Guy A. Rouleau,Ziv Gan-Or,Ziv Gan-Or +16 more
TL;DR: In this article, the authors performed two-sample Mendelian randomization and linkage disequilibrium score regression using summary statistics from recent genome-wide meta-analyses of Parkinson's disease and restless legs syndrome.