Guy A. Rouleau

TL;DR: The first known medical description of Tourette syndrome was given by Gilles de la Tourette as discussed by the authors in 1825, based on two cases, one of which was later followed by Jean-Martin Charcot.

TL;DR: This report revealed a previously unreported mutation, which will affect the WNK1/HSN2 isoforms of W NK1 and not only the HSN2 coding region, and so it has been presented in a confusing manner for readers who may not be aware that the H SN2 region is in fact an exon of WNK 1.

TL;DR: It is demonstrated that coexpression patterns from human post-mortem brain samples are significantly correlated with the transcriptional consequences of CRISPR perturbations of 15 neurodevelopmental genes in neuronal cell models, and leveraging convergent coexpression can identify novel ASD risk genes that are more likely to be underpowered and therefore missed by current large-scale sequencing studies.

TL;DR: This study confirms the increased RLS risk in mothers of ADHD (and TS, most likely) children (with unknown paternal information due to the study design) and observes a significant association between presence of ADHD in the offspring and risk of having RLS.