G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
FET proteins regulate lifespan and neuronal integrity.
Martine Therrien,Guy A. Rouleau,Guy A. Rouleau,Patrick A. Dion,Patrick A. Dion,J. Alex Parker +5 more
TL;DR: It is shown that a reduction of FET proteins in the nematode Caenorhabditis elegans causes synaptic dysfunction accompanied by impaired motor phenotypes, and it is proposed that Fet proteins are involved in the maintenance of lifespan, cellular stress resistance and neuronal integrity.
Journal ArticleDOI
SPTAN1 variants as a potential cause for autosomal recessive hereditary spastic paraplegia.
Etienne Leveille,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Lynne Krohn,Dan Spiegelman,Dan Spiegelman,Alexandre Dionne-Laporte,Alexandre Dionne-Laporte,Nicolas Dupré,Jean-François Trempe,Guy A. Rouleau,Guy A. Rouleau,Ziv Gan-Or,Ziv Gan-Or +13 more
TL;DR: The phenotype of SPTAN1 mutations, which at the heterozygous state, when occurred de novo, may cause early infantile epileptic encephalopathy-5 (EIEE5), is expanded to include in genetic screening panels for genetically undiagnosed HSP patients.
Posted ContentDOI
Genome-Wide Association Study Meta-Analysis for Parkinson’s Disease Motor Subtypes
Isabel Alfradique-Dunham,Isabel Alfradique-Dunham,Rami Al-Ouran,Rami Al-Ouran,Rainer von Coelln,Cornelis Blauwendraat,Emily Hill,Lan Luo,Lan Luo,Amanda Stillwell,Emily Young,Manuela Tan,Calwing Liao,Calwing Liao,Dena G. Hernandez,Lasse Pihlstrøm,Donald G. Grosset,Lisa M. Shulman,Zhandong Liu,Zhandong Liu,Guy A. Rouleau,Guy A. Rouleau,Mike A. Nalls,Andrew B. Singleton,Huw R. Morris,Joseph Jankovic,Joshua M. Shulman +26 more
TL;DR: The discovery of a novel variant at STK32B suggests a possible overlap between genetic risk for essential tremor and tremor-dominant PD and multiple PD risk alleles may also modify clinical manifestations to influence PD motor subtype.
Journal ArticleDOI
Transmission disequilibrium study of an oligodendrocyte and myelin glycoprotein gene allele in 431 families with an autistic proband
Isabelle Martin,Julie Gauthier,Marcello D'Amelio,Sylviane Védrine,Patrick Vourc'h,Guy A. Rouleau,Antonio M. Persico,Christian R. Andres +7 more
TL;DR: The associations observed in Japanese and French patients, the linkage studies and the present work speak in favor of the existence of a susceptibility gene for autism in the NF1 locus.
Journal ArticleDOI
CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia.
Lan Xiong,Guy A. Rouleau,Lynn E. DeLisi,Judith St-Onge,Robert Najafee,Jean-Baptiste Rivière,Chawki Benkelfat,Karim Tabbane,Ferid Fathalli,Zoltan Danics,Alain Labelle,Samarthji Lal,Ridha Joober +12 more
TL;DR: The Nogo gene was putatively implicated in schizophrenia based on gene expression and genetic association data and genotyping results indicated that neither the trinucleotide insertion polymorphism nor the polymorphism-TATC deletion with schizophrenia is significantly different in patients compared to controls.