G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients.
Klaus Oliver Schubert,Klaus Oliver Schubert,Anbupalam Thalamuthu,Azmeraw T. Amare,Joseph Frank,Fabian Streit,Mazda Adl,Nirmala Akula,Kazufumi Akiyama,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Abesh Kumar Bhattacharjee,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Joanna M. Biernacka,Armin Birner,Cynthia Marie-Claire,Micah Cearns,Pablo Cervantes,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Scott R. Clark,Cristiana Cruceanu,Piotr M. Czerski,Nina Dalkner,Alexandre Dayer,Franziska Degenhardt,Maria Del Zompo,J. Raymond DePaulo,Bruno Etain,Peter Falkai,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Paul Grof,Ryota Hashimoto,Joanna Hauser,Urs Heilbronner,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Liping Hou,Yi-Hsiang Hsu,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Po-Hsiu Kuo,Tadafumi Kato,John R. Kelsoe,Sarah Kittel-Schneider,Ewa Ferensztajn-Rochowiak,Barbara König,Ichiro Kusumi,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Mario Maj,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Michael McCarthy,Susan L. McElroy,Francesc Colom,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,Claire O'Donovan,Norio Ozaki,Urban Ösby,Sergi Papiol,Andrea Pfennig,Claudia Pisanu,James B. Potash,Andreas Reif,Eva Z. Reininghaus,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Barbara W. Schweizer,Giovanni Severino,Tatyana Shekhtman,Paul D. Shilling,Katzutaka Shimoda,Christian Simhandl,Claire Slaney,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Fasil Tekola-Ayele,Alfonso Tortorella,Gustavo Turecki,Julia Veeh,Eduard Vieta,Stephanie H. Witt,Gloria Roberts,Peter P. Zandi,Martin Alda,Michael Bauer,Francis J. McMahon,Philip B. Mitchell,Thomas G. Schulze,Marcella Rietschel,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune +128 more
TL;DR: In this paper, the authors used fixed effect meta-analysis techniques to develop meta-analytic polygenic risk scores (MET-PRS) from combinations of highly correlated psychiatric traits, namely schizophrenia (SCZ), major depression (MD) and bipolar disorder (BD).
Journal ArticleDOI
Quantitative trait loci (QTL) study identifies novel genomic regions associated to Chiari-like malformation in Griffon Bruxellois dogs.
Philippe Lemay,Susan P. Knowler,Samir Bouasker,Yohann Nédélec,Simon R. Platt,Courtenay Freeman,Georgina Child,Luis B. Barreiro,Guy A. Rouleau,Clare Rusbridge,Zoha Kibar +10 more
TL;DR: This study demonstrates the implication of multiple traits in the etiology of CM and has successfully identified two new QTL associated to CM and a potential candidate gene.
Journal ArticleDOI
Evidence for the existence of a fourth dominantly inherited spinocerebellar ataxia locus.
TL;DR: Linkage analysis using anonymous DNA markers that flank the three previously described loci significantly exclude the French-Canadian kindred from the SCA1, SCA2, and MJD loci, suggesting a fourth, still unmapped SCA locus remains to be identified.
Journal ArticleDOI
Clinical and genetic analysis of ATP13A2 in hereditary spastic paraplegia expands the phenotype
Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Etienne Leveille,Dan Spiegelman,Dan Spiegelman,Nicolas Dupré,Jean-François Trempe,Guy A. Rouleau,Guy A. Rouleau,Ziv Gan-Or,Ziv Gan-Or +10 more
TL;DR: Hereditary spastic paraplegias (HSP) are neurodegenerative disorders characterized by lower limb spasticity and weakness, with or without additional symptoms.
Journal ArticleDOI
Polyglutamine coding genes in bipolar disorder: lack of association with selected candidate loci.
Gustavo Turecki,Martin Alda,Martin Alda,Paul Grof,Ridha Joober,Ronald G. Lafrenière,P. Cavazzoni,Anne Duffy,Eva Grof,B. Ahrens,Anne Berghöfer,B. Müller-Oerlinghausen,M Dvoráková,E Libigerová,M Vojtechovský,Petr Zvolský,A Nilsson,H Prochazka,Rasmus Wentzer Licht,N A Rasmussen,Mogens Schou,Per Vestergaard,A Holzinger,C Schumann,Kenneth Thau,Guy A. Rouleau +25 more
TL;DR: The results suggest that the loci investigated have no major role in the genetic predisposition to bipolar disorder, and are likely to have a small proportion of the total genetic variability.