G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Reassessing GWAS findings for the shared genetic basis of insomnia and restless legs syndrome
Maryam El Gewely,Mélanie Welman,Lan Xiong,Lan Xiong,Sophie Yin,Hélène Catoire,Guy A. Rouleau,Jacques Montplaisir,Alex Desautels,Simon C. Warby +9 more
TL;DR: The data confirms thatMEIS1 is a genetic risk factor for the development of RLS, but it does not support the pleiotropic effect of MEIS1 in CID.
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ALS predisposition modifiers: knock NOX, who's there? SOD1 mice still are.
TL;DR: It was observed that one of the redox-related genes, which is specifically upregulated in activated microglia in spinal cords responding in ALS, is NOX2, and it could be predicted that motor neurons would have less damaging and fewer insults from activatedmicroglia.
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Assessing non-Mendelian inheritance in inherited axonopathies.
Dana M. Bis-Brewer,Ziv Gan-Or,Ziv Gan-Or,Patrick M. A. Sleiman,Hakon Hakonarson,Sarah Fazal,Steve Courel,Vívian Pedigone Cintra,Feifei Tao,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Mark A. Tarnopolsky,Kym M. Boycott,Grace Yoon,Oksana Suchowersky,Nicolas Dupré,Andrew F. Cheng,Thomas E. Lloyd,Guy A. Rouleau,Guy A. Rouleau,Rebecca Schüle,Stephan Züchner +21 more
TL;DR: The results support the continuing emergence of complex inheritance mechanisms in historically Mendelian disorders and explore the possibility of multilocus inheritance in IA.
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No evidence for GADL1 variation as a bipolar disorder susceptibility factor in a Caucasian lithium-responsive cohort.
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Increased Missense Mutation Burden of Fatty Acid Metabolism Related Genes in Nunavik Inuit Population
Sirui Zhou,Lan Xiong,Pingxing Xie,Amirthagowri Ambalavanan,Cynthia V. Bourassa,Alexandre Dionne-Laporte,Dan Spiegelman,Maude Turcotte Gauthier,Edouard Henrion,Ousmane Diallo,Patrick A. Dion,Guy A. Rouleau +11 more
TL;DR: The increased number and frequency of deleterious variants in these fatty acid metabolism genes in Nunavik Inuit may be the result of genetic adaptation to their diet and/or the extremely cold climate, and the identification of these variants may help to understand some of the specific health risks of Nunavk Inuit.