G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19
Yuji Takahashi,Yoko Fukuda,Jun Yoshimura,Atsushi Toyoda,Kari J. Kurppa,Hiroyoko Moritoyo,Veronique V. Belzil,Patrick A. Dion,Patrick A. Dion,Koichiro Higasa,Koichiro Doi,Hiroyuki Ishiura,Jun Mitsui,Hidetoshi Date,Budrul Ahsan,Takashi Matsukawa,Yaeko Ichikawa,Takashi Moritoyo,Mayumi Ikoma,Tsukasa Hashimoto,Fumiharu Kimura,Shigeo Murayama,Osamu Onodera,Masatoyo Nishizawa,Mari Yoshida,Naoki Atsuta,Gen Sobue,Jennifer A. Fifita,Jennifer A. Fifita,Kelly L. Williams,Kelly L. Williams,Ian P. Blair,Ian P. Blair,Garth A. Nicholson,Paloma Gonzalez-Perez,Robert H. Brown,Masahiro Nomoto,Klaus Elenius,Klaus Elenius,Guy A. Rouleau,Guy A. Rouleau,Guy A. Rouleau,Asao Fujiyama,Shinichi Morishita,Jun Goto,Shoji Tsuji +45 more
TL;DR: It is indicated that disruption of the neuregulin-ErbBB4 pathway is involved in the pathogenesis of ALS and potentially paves the way for the development of innovative therapeutic strategies such using NRGs or their agonists to upregulate ErbB4 functions.
Journal ArticleDOI
Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis
Hannah M. Kaneb,Hannah M. Kaneb,Andrew W. Folkmann,Veronique V. Belzil,Li-En Jao,Claire S. Leblond,Simon Girard,Hussein Daoud,Anne Noreau,Daniel Rochefort,Pascale Hince,Anna Szuto,Annie Levert,Sabrina Vidal,Catherine André-Guimont,William Camu,Jean-Pierre Bouchard,Nicolas Dupré,Guy A. Rouleau,Susan R. Wente,Patrick A. Dion,Patrick A. Dion +21 more
TL;DR: The first screening of GLE1 in ALS patients found 2 deleterious mutations to be unable to rescue motor neuron pathology in zebrafish morphants lacking Gle1, and a haploinsufficiency mechanism is suggested that supports the involvement of global defects in RNA metabolism in ALS.
Journal ArticleDOI
A Variant in XPNPEP2 Is Associated with Angioedema Induced by Angiotensin I–Converting Enzyme Inhibitors
Qing Ling Duan,Borzoo Nikpoor,Marie-Pierre Dubé,Giuseppe Molinaro,Inge A. Meijer,Patrick A. Dion,Daniel Rochefort,Judith Saint-Onge,Leah Flury,Nancy J. Brown,James V. Gainer,Jean L. Rouleau,Angelo Agostoni,Massimo Cugno,Pierre Simon,Pierre Clavel,Jacky Potier,Bassem Wehbe,Seddik Benarbia,Julien Marc-Aurèle,J Chanard,Tatiana Foroud,Albert Adam,Guy A. Rouleau +23 more
TL;DR: Supporting evidence is provided that the C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi, a potentially life-threatening adverse reaction known as angioedema.
Journal ArticleDOI
Genome scan for tourette disorder in affected-sibling-pair and multigenerational families
David L. Pauls,Danielle C. Cath,Peter Heutink,Marco A. Grados,Harvey S. Singer,John T. Walkup,Cornelia Illmann,Jeremiah M. Scharf,Susan L. Santangelo,S. E. Stewart,Jill Platko,D. L. Pauls,Nancy J. Cox,Mary M. Robertson,Dianne Keen-Kim,Chiara Sabatti,Nelson B. Freimer,Guy A. Rouleau,Jean-Baptiste Rivière,Sylvain Chouinard,Francois Richer,Paul Lespérance,Yves Dion,Robert A. King,J.R. Kidd,A.J. Pakstis,James F. Leckman,Kenneth K. Kidd,G. Gericke,Roger Kurlan,Peter Como,Donna Palumbo,Annemieke J.M.H. Verkerk,Ben A. Oostra,William M. McMahon,Mark Leppert,Hilary Coon,Carol A. Mathews,Paul Sandor,Cathy L. Barr,Christine Bétard,D. Zelenika +41 more
TL;DR: The results of the largest genetic linkage study yet undertaken for Tourette disorder provide strong evidence of linkage for a region on chromosome 2p and results in several other regions provide moderate evidence of additional susceptibility loci for TD.
Journal ArticleDOI
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.
Anny Fortin,Eduardo Diez,Daniel Rochefort,Line Laroche,Danielle Malo,Danielle Malo,Guy A. Rouleau,Guy A. Rouleau,Philippe Gros,Philippe Gros,Emil Skamene,Emil Skamene +11 more
TL;DR: The creation of a series of 37 independent RCS derived from the commonly used inbred strains of laboratory mouse A/J (A) and C57BL/6J (B6) should prove a useful tool with which to investigate the complex genetic basis of known interstrain differences between A and B6 for many important diseases.