G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Polyglutamine-containing proteins in neuropsychiatric disorders
Guy A. Rouleau,Ridha Joober +1 more
TL;DR: In this article, the authors proposed a method for the diagnosis and treatment of neuropsychiatric disorders caused by CAG repeat expansions and even more particularly to schizophrenia and major depression, by detecting nucleic acids encoding the polyglutamine tract in a sample.
Posted ContentDOI
Genetic, structural and clinical analysis of spastic paraplegia 4
Parizad Varghaei,Parizad Varghaei,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Setareh Ashtiani,Simon Veyron,Kheireddin Mufti,Kheireddin Mufti,Etienne Leveille,Eric Yu,Eric Yu,Dan Spiegelman,Marie-France Rioux,Grace Yoon,Mark A. Tarnopolsky,Kym M. Boycott,Nicolas Dupré,Oksana Suchowersky,Oksana Suchowersky,Jean-François Trempe,Guy A. Rouleau,Guy A. Rouleau,Ziv Gan-Or,Ziv Gan-Or +23 more
TL;DR: In this article, the SPAST gene was analyzed in a total of 696 hereditary spastic paraplegia type 4 (SPG4) patients from 431 families by either HSP-gene panel sequencing or whole exome sequencing.
Journal ArticleDOI
Mutations de novo de SYNGAP1 associées à la déficience intellectuelle non syndromique
TL;DR: Les familles dans lesquelles la DI est transmise sur le mode autosomique dominant sont rares en raison d’un taux de reproduction inferieur a celui de the population generale, anders au developpement of the DINS.
Journal ArticleDOI
Diagnostic Yield of Whole Exome Sequencing for Adults with Ataxia: a Brazilian Perspective.
Felipe Franco da Graça,Thiago Mazzo Peluzzo,Luciana Cardoso Bonadia,Alberto R. M. Martinez,Fabrício Diniz de Lima,José Luiz Pedroso,Orlando Graziani Povoas Barsottini,Maria Thereza Drummond Gama,Fulya Akçimen,Fulya Akçimen,Patrick A. Dion,Patrick A. Dion,Guy A. Rouleau,Guy A. Rouleau,Wilson Marques,Marcondes C. França +15 more
TL;DR: In this article, the authors used whole exome sequencing (WES) to investigate a Brazilian cohort of 76 adults with idiopathic ataxia previously screened for trinucleotide expansions in known ataxias genes.
Journal ArticleDOI
Transcriptomic effects of propranolol and primidone converge on molecular pathways relevant to essential tremor
Charles-Etienne Castonguay,Calwing Liao,Anouar Khayachi,Yumin Liu,Miranda Medeiros,Gabrielle Houle,Jay P. Ross,Patrick A. Dion,Guy A. Rouleau +8 more
TL;DR: In this paper , RNA-sequencing was used to identify convergent differentially expressed genes across treatments for essential tremor (ET) in cerebellar DAOY and neural progenitor cells.